Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer
Purpose This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC). Methods Between 1996 and 2019, patients who were diagnosed with both BrC and CRC were evaluated retrospectively. Patients with distant metastasis...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Coloproctology
2022-06-01
|
| Series: | Annals of Coloproctology |
| Subjects: | |
| Online Access: | http://coloproctol.org/upload/pdf/ac-2021-00640-0091.pdf |
| _version_ | 1818469867450269696 |
|---|---|
| author | Hyundo Lee Hae Won Lee Eun Jung Park Jeonghyun Kang Seung Hyuk Baik |
| author_facet | Hyundo Lee Hae Won Lee Eun Jung Park Jeonghyun Kang Seung Hyuk Baik |
| author_sort | Hyundo Lee |
| collection | DOAJ |
| description | Purpose This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC). Methods Between 1996 and 2019, patients who were diagnosed with both BrC and CRC were evaluated retrospectively. Patients with distant metastasis, palliative resection, and previous cancer histories except for BrCs or CRCs were excluded. Altogether, 105 patients were divided into the B=C group (n=21), B-first group (n=40), and C-first group (n=44) according to the definition of synchronous and metachronous cancers. The clinicopathologic features and overall survival were evaluated. Results TNM stages and histologic types were comparable among the 3 groups (P=0.434). The interval of diagnosis was 67.1±40.4 and 59.3±47.2 months in the B- and C-first groups, respectively. The incidence of adjuvant chemotherapy in the B-first group was 57.5%, which was higher than the B=C and C-first groups (P<0.001). The estrogen receptor, progesterone receptor, Ki-67, and HER-2 molecular markers were not significantly different among the groups. The overall survival of the B-first group showed lower survival rates than the C-first group (P=0.039). In the logistic regression, HER-2 status (hazard ratio [HR], 11.9; P=0.032) and lymph node metastasis of CRC (HR, 5.8; P=0.036) were prognostic factors affecting overall survival. Conclusion B-first group had poorer survival outcomes than the C-first group in patients with the metachronous BrC and CRC. HER2 positivity and CRC lymph node metastasis may be prognostic factors that affect overall survival in these patients. The findings support that a colorectal cancer screening program should be included during BrC surveillance. |
| first_indexed | 2024-04-13T21:30:23Z |
| format | Article |
| id | doaj.art-184085c04b7549e4af4c01bf6c757807 |
| institution | Directory Open Access Journal |
| issn | 2287-9714 2287-9722 |
| language | English |
| last_indexed | 2024-04-13T21:30:23Z |
| publishDate | 2022-06-01 |
| publisher | Korean Society of Coloproctology |
| record_format | Article |
| series | Annals of Coloproctology |
| spelling | doaj.art-184085c04b7549e4af4c01bf6c7578072022-12-22T02:29:11ZengKorean Society of ColoproctologyAnnals of Coloproctology2287-97142287-97222022-06-0138319720610.3393/ac.2021.00640.00911873Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancerHyundo Lee0Hae Won Lee1Eun Jung Park2Jeonghyun Kang3Seung Hyuk Baik4 Department of Surgery, Yonsei University College of Medicine, Seoul, Korea Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Colon and Rectal Surgery, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Division of Colon and Rectal Surgery, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Division of Colon and Rectal Surgery, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaPurpose This study aimed to investigate the clinicopathologic features and survival in patients with both breast cancer (BrC) and colorectal cancer (CRC). Methods Between 1996 and 2019, patients who were diagnosed with both BrC and CRC were evaluated retrospectively. Patients with distant metastasis, palliative resection, and previous cancer histories except for BrCs or CRCs were excluded. Altogether, 105 patients were divided into the B=C group (n=21), B-first group (n=40), and C-first group (n=44) according to the definition of synchronous and metachronous cancers. The clinicopathologic features and overall survival were evaluated. Results TNM stages and histologic types were comparable among the 3 groups (P=0.434). The interval of diagnosis was 67.1±40.4 and 59.3±47.2 months in the B- and C-first groups, respectively. The incidence of adjuvant chemotherapy in the B-first group was 57.5%, which was higher than the B=C and C-first groups (P<0.001). The estrogen receptor, progesterone receptor, Ki-67, and HER-2 molecular markers were not significantly different among the groups. The overall survival of the B-first group showed lower survival rates than the C-first group (P=0.039). In the logistic regression, HER-2 status (hazard ratio [HR], 11.9; P=0.032) and lymph node metastasis of CRC (HR, 5.8; P=0.036) were prognostic factors affecting overall survival. Conclusion B-first group had poorer survival outcomes than the C-first group in patients with the metachronous BrC and CRC. HER2 positivity and CRC lymph node metastasis may be prognostic factors that affect overall survival in these patients. The findings support that a colorectal cancer screening program should be included during BrC surveillance.http://coloproctol.org/upload/pdf/ac-2021-00640-0091.pdfneoplasmsbreast neoplasmscolorectal neoplasmssurvival |
| spellingShingle | Hyundo Lee Hae Won Lee Eun Jung Park Jeonghyun Kang Seung Hyuk Baik Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer Annals of Coloproctology neoplasms breast neoplasms colorectal neoplasms survival |
| title | Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer |
| title_full | Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer |
| title_fullStr | Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer |
| title_full_unstemmed | Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer |
| title_short | Clinicopathologic characteristics and survival of patients with double primary malignancies: breast and colorectal cancer |
| title_sort | clinicopathologic characteristics and survival of patients with double primary malignancies breast and colorectal cancer |
| topic | neoplasms breast neoplasms colorectal neoplasms survival |
| url | http://coloproctol.org/upload/pdf/ac-2021-00640-0091.pdf |
| work_keys_str_mv | AT hyundolee clinicopathologiccharacteristicsandsurvivalofpatientswithdoubleprimarymalignanciesbreastandcolorectalcancer AT haewonlee clinicopathologiccharacteristicsandsurvivalofpatientswithdoubleprimarymalignanciesbreastandcolorectalcancer AT eunjungpark clinicopathologiccharacteristicsandsurvivalofpatientswithdoubleprimarymalignanciesbreastandcolorectalcancer AT jeonghyunkang clinicopathologiccharacteristicsandsurvivalofpatientswithdoubleprimarymalignanciesbreastandcolorectalcancer AT seunghyukbaik clinicopathologiccharacteristicsandsurvivalofpatientswithdoubleprimarymalignanciesbreastandcolorectalcancer |