Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up
Abstract Background As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyo...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-06960-9 |
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| author | Kristiina Vuolukka Päivi Auvinen Jan-Erik Palmgren Sirpa Aaltomaa Vesa Kataja |
| author_facet | Kristiina Vuolukka Päivi Auvinen Jan-Erik Palmgren Sirpa Aaltomaa Vesa Kataja |
| author_sort | Kristiina Vuolukka |
| collection | DOAJ |
| description | Abstract Background As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy in the original treatment field can be considered as radiation-induced subsequent primary cancers (RISPCs). Methods During the years 1999-2008, 241 patients with localized PCa who underwent low dose-rate brachytherapy (LDR-BT) with I125 and were followed-up in Kuopio University Hospital, were included in this study. In this study the incidences and types of SPCs and RISPCs with a very long follow-up time after LDR-BT were evaluated. Results During the median follow-up time of 11.4 years, a total of 34 (14.1%) patients developed a metachronous SPC. The most abundant SPCs were lung and colorectal cancers, each diagnosed in six patients (16.7% out of all SPCs). The crude incidence rate of RISPC was 1.7% (n = 4). Half of the SPC cases (50%) were diagnosed during the latter half of the follow-up time as the risk to develop an SPC continued throughout the whole follow-up time with the actuarial 10-year SPC rate of 7.0%. The crude death rates due to metachronous out-of-field SPCs and RISPCs were 50 and 50%, respectively. Conclusion The crude rate of SPC was in line with previously published data and the incidence of RISPC was very low. These results support the role of LDR-BT as a safe treatment option for patients with localized PCa. |
| first_indexed | 2024-12-13T11:29:40Z |
| format | Article |
| id | doaj.art-18429d5291ce43188f143f222b837909 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T11:29:40Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-18429d5291ce43188f143f222b8379092022-12-21T23:48:00ZengBMCBMC Cancer1471-24072020-05-012011610.1186/s12885-020-06960-9Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-upKristiina Vuolukka0Päivi Auvinen1Jan-Erik Palmgren2Sirpa Aaltomaa3Vesa Kataja4Cancer Center, Kuopio University HospitalCancer Center, Kuopio University HospitalCancer Center, Kuopio University HospitalDepartment of Urology, Kuopio University HospitalUniversity of Eastern FinlandAbstract Background As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an additional risk factor for cancer development and the SPCs appearing beyond 5 years after radiotherapy in the original treatment field can be considered as radiation-induced subsequent primary cancers (RISPCs). Methods During the years 1999-2008, 241 patients with localized PCa who underwent low dose-rate brachytherapy (LDR-BT) with I125 and were followed-up in Kuopio University Hospital, were included in this study. In this study the incidences and types of SPCs and RISPCs with a very long follow-up time after LDR-BT were evaluated. Results During the median follow-up time of 11.4 years, a total of 34 (14.1%) patients developed a metachronous SPC. The most abundant SPCs were lung and colorectal cancers, each diagnosed in six patients (16.7% out of all SPCs). The crude incidence rate of RISPC was 1.7% (n = 4). Half of the SPC cases (50%) were diagnosed during the latter half of the follow-up time as the risk to develop an SPC continued throughout the whole follow-up time with the actuarial 10-year SPC rate of 7.0%. The crude death rates due to metachronous out-of-field SPCs and RISPCs were 50 and 50%, respectively. Conclusion The crude rate of SPC was in line with previously published data and the incidence of RISPC was very low. These results support the role of LDR-BT as a safe treatment option for patients with localized PCa.http://link.springer.com/article/10.1186/s12885-020-06960-9Prostate cancerLow dose-rate brachytherapySubsequent primary cancerRadiation induced subsequent primary cancer |
| spellingShingle | Kristiina Vuolukka Päivi Auvinen Jan-Erik Palmgren Sirpa Aaltomaa Vesa Kataja Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up BMC Cancer Prostate cancer Low dose-rate brachytherapy Subsequent primary cancer Radiation induced subsequent primary cancer |
| title | Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up |
| title_full | Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up |
| title_fullStr | Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up |
| title_full_unstemmed | Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up |
| title_short | Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up |
| title_sort | incidence of subsequent primary cancers and radiation induced subsequent primary cancers after low dose rate brachytherapy monotherapy for prostate cancer in long term follow up |
| topic | Prostate cancer Low dose-rate brachytherapy Subsequent primary cancer Radiation induced subsequent primary cancer |
| url | http://link.springer.com/article/10.1186/s12885-020-06960-9 |
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