The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh
Abstract Background Evidence suggests that daily supplementation of 1500 to 2000 mg of calcium during pregnancy reduces pregnancy-induced hypertension (PIH). However, the evidence on the efficacy of low-dose calcium supplementation on PIH is limited. This paper assesses the longitudinal correlation...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-10-01
|
| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12884-018-2046-0 |
| _version_ | 1818542176790904832 |
|---|---|
| author | Fouzia Khanam Belal Hossain Sabuj Kanti Mistry Dipak K. Mitra Wameq Azfar Raza Mahfuza Rifat Kaosar Afsana Mahfuzar Rahman |
| author_facet | Fouzia Khanam Belal Hossain Sabuj Kanti Mistry Dipak K. Mitra Wameq Azfar Raza Mahfuza Rifat Kaosar Afsana Mahfuzar Rahman |
| author_sort | Fouzia Khanam |
| collection | DOAJ |
| description | Abstract Background Evidence suggests that daily supplementation of 1500 to 2000 mg of calcium during pregnancy reduces pregnancy-induced hypertension (PIH). However, the evidence on the efficacy of low-dose calcium supplementation on PIH is limited. This paper assesses the longitudinal correlation between low-dose calcium intake (500 mg daily) and change in blood pressure during pregnancy among a homogeneous population in terms of hypertension and pre-eclampsia. Methods The study followed a retrospective cohort study design, and was carried out among 11,387 pregnant women from 10 rural upazilas (sub-districts) of Bangladesh where maternal nutrition initiative (MNI), implemented by Building Resources Across Communities (BRAC), was ongoing. The modified Poisson regression model was used to estimate the association (risk ratio) between consumption of calcium tablets and PIH. Results The present research found that women who consumed 500 mg/d calcium tablets for more than 6 months during their pregnancy had a 45% lower risk of developing hypertension compared to those who consumed less calcium (RR = 0.55, 95% CI = 0.33–0.93). Conclusions Daily supplementation of 500 mg oral calcium during pregnancy for at least 180 tablets is associated with a considerably reduced risk of PIH, but this study is unable to confirm whether this association is causal. The causal relationship needs to be confirmed through a large scale randomized controlled trial. |
| first_indexed | 2024-12-11T22:18:41Z |
| format | Article |
| id | doaj.art-1843832c6a1340f3809509f396a05613 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-11T22:18:41Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-1843832c6a1340f3809509f396a056132022-12-22T00:48:31ZengBMCBMC Pregnancy and Childbirth1471-23932018-10-011811910.1186/s12884-018-2046-0The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in BangladeshFouzia Khanam0Belal Hossain1Sabuj Kanti Mistry2Dipak K. Mitra3Wameq Azfar Raza4Mahfuza Rifat5Kaosar Afsana6Mahfuzar Rahman7Research and Evaluation Division, BRAC CenterResearch and Evaluation Division, BRAC CenterResearch and Evaluation Division, BRAC CenterDepartment of Public Health, North South UniversityPoverty and Equity, The World BankHealth, Nutrition and Population Program, BRAC CenterHealth, Nutrition and Population Program, BRAC CenterResearch and Evaluation Division, BRAC CenterAbstract Background Evidence suggests that daily supplementation of 1500 to 2000 mg of calcium during pregnancy reduces pregnancy-induced hypertension (PIH). However, the evidence on the efficacy of low-dose calcium supplementation on PIH is limited. This paper assesses the longitudinal correlation between low-dose calcium intake (500 mg daily) and change in blood pressure during pregnancy among a homogeneous population in terms of hypertension and pre-eclampsia. Methods The study followed a retrospective cohort study design, and was carried out among 11,387 pregnant women from 10 rural upazilas (sub-districts) of Bangladesh where maternal nutrition initiative (MNI), implemented by Building Resources Across Communities (BRAC), was ongoing. The modified Poisson regression model was used to estimate the association (risk ratio) between consumption of calcium tablets and PIH. Results The present research found that women who consumed 500 mg/d calcium tablets for more than 6 months during their pregnancy had a 45% lower risk of developing hypertension compared to those who consumed less calcium (RR = 0.55, 95% CI = 0.33–0.93). Conclusions Daily supplementation of 500 mg oral calcium during pregnancy for at least 180 tablets is associated with a considerably reduced risk of PIH, but this study is unable to confirm whether this association is causal. The causal relationship needs to be confirmed through a large scale randomized controlled trial.http://link.springer.com/article/10.1186/s12884-018-2046-0Pregnancy-induced hypertensionCalcium supplementationMaternal nutrition initiative (MNI)Global healthMaternal mortality |
| spellingShingle | Fouzia Khanam Belal Hossain Sabuj Kanti Mistry Dipak K. Mitra Wameq Azfar Raza Mahfuza Rifat Kaosar Afsana Mahfuzar Rahman The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh BMC Pregnancy and Childbirth Pregnancy-induced hypertension Calcium supplementation Maternal nutrition initiative (MNI) Global health Maternal mortality |
| title | The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh |
| title_full | The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh |
| title_fullStr | The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh |
| title_full_unstemmed | The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh |
| title_short | The association between daily 500 mg calcium supplementation and lower pregnancy-induced hypertension risk in Bangladesh |
| title_sort | association between daily 500 mg calcium supplementation and lower pregnancy induced hypertension risk in bangladesh |
| topic | Pregnancy-induced hypertension Calcium supplementation Maternal nutrition initiative (MNI) Global health Maternal mortality |
| url | http://link.springer.com/article/10.1186/s12884-018-2046-0 |
| work_keys_str_mv | AT fouziakhanam theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT belalhossain theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT sabujkantimistry theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT dipakkmitra theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT wameqazfarraza theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT mahfuzarifat theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT kaosarafsana theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT mahfuzarrahman theassociationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT fouziakhanam associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT belalhossain associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT sabujkantimistry associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT dipakkmitra associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT wameqazfarraza associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT mahfuzarifat associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT kaosarafsana associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh AT mahfuzarrahman associationbetweendaily500mgcalciumsupplementationandlowerpregnancyinducedhypertensionriskinbangladesh |