A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System

A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System

The evaluation of inhalation toxicity, drug safety and efficacy assessment, as well as the investigation of complex disease pathomechanisms, are increasingly relying on in vitro lung models. This is due to the progressive shift towards human-based systems for more predictive and translational resear...

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Bibliographic Details
Main Authors: Arunima Sengupta, Nuria Roldan, Mirjam Kiener, Laurène Froment, Giulia Raggi, Theo Imler, Lea de Maddalena, Aude Rapet, Tobias May, Patrick Carius, Nicole Schneider-Daum, Claus-Michael Lehr, Marianna Kruithof-de Julio, Thomas Geiser, Thomas Michael Marti, Janick D. Stucki, Nina Hobi, Olivier T. Guenat
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Toxicology
Subjects:
alveolar epithelial cells
distal lung
lung-on-a-chip
SARS-CoV-2
cyclic stretch
lung inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.840606/full

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