Drosophila at the intersection of infection, inflammation and cancer

Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying k...

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Main Author: Erdem eBangi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00103/full
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author Erdem eBangi
author_facet Erdem eBangi
author_sort Erdem eBangi
collection DOAJ
description Recent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK and JAK-STAT, microbial infection and inflammation during tumor progression.
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spelling doaj.art-1843b9aba25840ddb7473b13b985c0202022-12-22T01:38:16ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882013-12-01310.3389/fcimb.2013.0010367806Drosophila at the intersection of infection, inflammation and cancerErdem eBangi0Icahn School of Medicine at Mount SinaiRecent studies show that both cellular and humoral aspects of innate immunity play important roles during tumor progression. These interactions have traditionally been explored in vertebrate model systems. In recent years, Drosophila has emerged as a genetically tractable model system for studying key aspects of tumorigenesis including proliferation, invasion and metastasis. The absence of adaptive immunity in Drosophila provides a unique opportunity to study the interactions between innate immune system and cancer in different genetic contexts. In this review, I discuss recent advances made by using Drosophila models of cancer to study the role of innate immune pathways Toll/Imd, JNK and JAK-STAT, microbial infection and inflammation during tumor progression.http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00103/fullDrosophilaInfectionInflammationCancerinnate immune response
spellingShingle Erdem eBangi
Drosophila at the intersection of infection, inflammation and cancer
Frontiers in Cellular and Infection Microbiology
Drosophila
Infection
Inflammation
Cancer
innate immune response
title Drosophila at the intersection of infection, inflammation and cancer
title_full Drosophila at the intersection of infection, inflammation and cancer
title_fullStr Drosophila at the intersection of infection, inflammation and cancer
title_full_unstemmed Drosophila at the intersection of infection, inflammation and cancer
title_short Drosophila at the intersection of infection, inflammation and cancer
title_sort drosophila at the intersection of infection inflammation and cancer
topic Drosophila
Infection
Inflammation
Cancer
innate immune response
url http://journal.frontiersin.org/Journal/10.3389/fcimb.2013.00103/full
work_keys_str_mv AT erdemebangi drosophilaattheintersectionofinfectioninflammationandcancer