Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia
Objective: To evaluate the utility of immature platelet fraction (IPF) as a marker in immune thrombocytopenia purpura (ITP) patients. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Haematology, Chughtai Institute of Pathology, Lahore Pakistan, from...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-10-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/PAFMJ/article/view/6728 |
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| author | Zahra Rashid Khan Ayisha Imran N.A.Malik |
| author_facet | Zahra Rashid Khan Ayisha Imran N.A.Malik |
| author_sort | Zahra Rashid Khan |
| collection | DOAJ |
| description |
Objective: To evaluate the utility of immature platelet fraction (IPF) as a marker in immune thrombocytopenia purpura (ITP)
patients.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Department of Haematology, Chughtai Institute of Pathology, Lahore Pakistan, from Aug to
Nov 2020.
Methodology: Sixty patients (Group-1) of immune thrombocytopenia purpura were selected. Sixty healthy individuals
(Group-2) with normal blood count parameters were also included. A complete blood count with simultaneous evaluation of immature platelet fraction was performed for both groups on 3ml peripheral blood collected in K2EDTA. To check the
reproducibility of results, each sample was run in duplicate.
Results: Group-1 had a mean platelet count of 43.77±32.82 x109 /L (range 2-98x109/L), a mean immature platelet fraction of 12.93±6.11% (range 3–25%) and a mean age 36.68±7.53 years, (range 22–56 years). Group-2 had a mean platelet count of 251.7±83.55 x109 /L (range 150-450 x109 /L), a mean immature platelet fraction of 3.78±1.86 %, (range 1-7.2%) and a mean age of 36.42±6.94 years, (range 22–55 years). ROC curve analysis yielded an immature platelet fraction value of 7.0% as the cut-off between immune thrombocytopenic purpura patients and healthy individuals.
Conclusion: Immature platelet fraction, though novel, is a useful marker to diagnose and monitor treatment response,
diagnosis and management of immune thrombocytopenic purpura.
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| first_indexed | 2024-03-08T10:11:24Z |
| format | Article |
| id | doaj.art-18443e01acbb4e28b1f95d90ae0b3493 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-08T10:11:24Z |
| publishDate | 2023-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-18443e01acbb4e28b1f95d90ae0b34932024-01-29T08:27:24ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-10-0173510.51253/pafmj.v73i5.6728Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated ThrombocytopeniaZahra Rashid Khan0Ayisha Imran1N.A.Malik2Department of Pathology, NUST School of Health Sciences, NUST Islamabad PakistanDepartment of Pathology, Chughtai Institute of Pathology, Lahore PakistanDepartment of Pathology, Chughtai Institute of Pathology, Lahore Pakistan Objective: To evaluate the utility of immature platelet fraction (IPF) as a marker in immune thrombocytopenia purpura (ITP) patients. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Haematology, Chughtai Institute of Pathology, Lahore Pakistan, from Aug to Nov 2020. Methodology: Sixty patients (Group-1) of immune thrombocytopenia purpura were selected. Sixty healthy individuals (Group-2) with normal blood count parameters were also included. A complete blood count with simultaneous evaluation of immature platelet fraction was performed for both groups on 3ml peripheral blood collected in K2EDTA. To check the reproducibility of results, each sample was run in duplicate. Results: Group-1 had a mean platelet count of 43.77±32.82 x109 /L (range 2-98x109/L), a mean immature platelet fraction of 12.93±6.11% (range 3–25%) and a mean age 36.68±7.53 years, (range 22–56 years). Group-2 had a mean platelet count of 251.7±83.55 x109 /L (range 150-450 x109 /L), a mean immature platelet fraction of 3.78±1.86 %, (range 1-7.2%) and a mean age of 36.42±6.94 years, (range 22–55 years). ROC curve analysis yielded an immature platelet fraction value of 7.0% as the cut-off between immune thrombocytopenic purpura patients and healthy individuals. Conclusion: Immature platelet fraction, though novel, is a useful marker to diagnose and monitor treatment response, diagnosis and management of immune thrombocytopenic purpura. https://www.pafmj.org/PAFMJ/article/view/6728Immature platelet fraction (IPF)Immune-mediated thrombocytopenic purpura (ITP)Reticulated platelets |
| spellingShingle | Zahra Rashid Khan Ayisha Imran N.A.Malik Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia Pakistan Armed Forces Medical Journal Immature platelet fraction (IPF) Immune-mediated thrombocytopenic purpura (ITP) Reticulated platelets |
| title | Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia |
| title_full | Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia |
| title_fullStr | Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia |
| title_full_unstemmed | Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia |
| title_short | Utility of Immature Platelet Fraction as Diagnostic Biomarker for Isolated Thrombocytopenia |
| title_sort | utility of immature platelet fraction as diagnostic biomarker for isolated thrombocytopenia |
| topic | Immature platelet fraction (IPF) Immune-mediated thrombocytopenic purpura (ITP) Reticulated platelets |
| url | https://www.pafmj.org/PAFMJ/article/view/6728 |
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