Subchronic Toxicity of the Physalis minima Leaves
The study was to evaluate the subchronic toxicity of aqueous extract of Physalis minima leaves in female rats. Eighteen female Wistar rats were orally administered with aqueous extract of P. minima leaves at doses of 90, 270 and 450 mg/kg BW, respectively for 90 days. Six female rats without any tre...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2018-08-01
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| Series: | Research Journal of Life Science |
| Subjects: | |
| Online Access: | http://rjls.ub.ac.id/index.php/rjls/article/view/171 |
| _version_ | 1811323438004961280 |
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| author | Setyawati Soeharto Dian Nugrahenny Nur Permatasari Elly Mayangsari |
| author_facet | Setyawati Soeharto Dian Nugrahenny Nur Permatasari Elly Mayangsari |
| author_sort | Setyawati Soeharto |
| collection | DOAJ |
| description | The study was to evaluate the subchronic toxicity of aqueous extract of Physalis minima leaves in female rats. Eighteen female Wistar rats were orally administered with aqueous extract of P. minima leaves at doses of 90, 270 and 450 mg/kg BW, respectively for 90 days. Six female rats without any treatment were provided as a control group. At the end of the experiment, blood samples were collected for hematological and biochemical (aspartate transaminase/AST, alanine transaminase/ALT, creatinine, urea, glucose, cholesterol, and triglyceride) analyses. The results showed that hematological and biochemical biomarkers were not significantly different in treated groups compared to the control group. It is concluded that the aqueous extract of P. minima leaves do not induce hematologic toxicity, hepatotoxicity and renal toxicity in the subchronic toxicity study. |
| first_indexed | 2024-04-13T13:55:09Z |
| format | Article |
| id | doaj.art-1845f2563e1d4603a5923749edb7d51f |
| institution | Directory Open Access Journal |
| issn | 2355-9926 |
| language | English |
| last_indexed | 2024-04-13T13:55:09Z |
| publishDate | 2018-08-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Research Journal of Life Science |
| spelling | doaj.art-1845f2563e1d4603a5923749edb7d51f2022-12-22T02:44:13ZengUniversity of BrawijayaResearch Journal of Life Science2355-99262018-08-0151778210.21776/ub.rjls.2018.005.01.8107Subchronic Toxicity of the Physalis minima LeavesSetyawati Soeharto0Dian Nugrahenny1Nur Permatasari2Elly Mayangsari3Department of Pharmacology, Faculty of Medicine, University of BrawijayaDepartment of Pharmacology, Faculty of Medicine, University of BrawijayaDepartment of Pharmacology, Faculty of Medicine, University of BrawijayaDepartment of Pharmacology, Faculty of Medicine, University of BrawijayaThe study was to evaluate the subchronic toxicity of aqueous extract of Physalis minima leaves in female rats. Eighteen female Wistar rats were orally administered with aqueous extract of P. minima leaves at doses of 90, 270 and 450 mg/kg BW, respectively for 90 days. Six female rats without any treatment were provided as a control group. At the end of the experiment, blood samples were collected for hematological and biochemical (aspartate transaminase/AST, alanine transaminase/ALT, creatinine, urea, glucose, cholesterol, and triglyceride) analyses. The results showed that hematological and biochemical biomarkers were not significantly different in treated groups compared to the control group. It is concluded that the aqueous extract of P. minima leaves do not induce hematologic toxicity, hepatotoxicity and renal toxicity in the subchronic toxicity study.http://rjls.ub.ac.id/index.php/rjls/article/view/171Physalis minimasub chronic toxicityrats |
| spellingShingle | Setyawati Soeharto Dian Nugrahenny Nur Permatasari Elly Mayangsari Subchronic Toxicity of the Physalis minima Leaves Research Journal of Life Science Physalis minima sub chronic toxicity rats |
| title | Subchronic Toxicity of the Physalis minima Leaves |
| title_full | Subchronic Toxicity of the Physalis minima Leaves |
| title_fullStr | Subchronic Toxicity of the Physalis minima Leaves |
| title_full_unstemmed | Subchronic Toxicity of the Physalis minima Leaves |
| title_short | Subchronic Toxicity of the Physalis minima Leaves |
| title_sort | subchronic toxicity of the physalis minima leaves |
| topic | Physalis minima sub chronic toxicity rats |
| url | http://rjls.ub.ac.id/index.php/rjls/article/view/171 |
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