Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine

Unveiling Integrated Functional Pathways Leading to Enhanced Respiratory Disease Associated With Inactivated Respiratory Syncytial Viral Vaccine

Respiratory syncytial virus (RSV) infection is a severe threat to young children and the elderly. Despite decades of research, no vaccine has been approved. Notably, instead of affording protection, a formalin-inactivated RSV vaccine induced severe respiratory disease including deaths in vaccinated...

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Bibliographic Details
Main Authors: Marsha S. Russell, Marybeth Creskey, Abenaya Muralidharan, Changgui Li, Jun Gao, Wangxue Chen, Louise Larocque, Jessie R. Lavoie, Aaron Farnsworth, Michael Rosu-Myles, Anwar M. Hashem, Carole L. Yauk, Jingxin Cao, Gary Van Domselaar, Terry Cyr, Xuguang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
RSV vaccines
RSV vaccine-enhanced disease
proteomics
systems biology
hypercoagulation
cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00597/full

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