Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword

Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword

Abstract In stressful or anxiety-provoking situations, most people with Parkinson’s disease (PD) experience a general worsening of motor symptoms, including their gait impairments. However, a proportion of patients actually report benefits from experiencing—or even purposely inducing—stressful or hi...

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Bibliographic Details
Main Authors: Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Translational Neurodegeneration
Subjects:
Arousal
Gait
Parkinson’s disease
Freezing of gait
Locus coeruleus
Online Access:https://doi.org/10.1186/s40035-023-00347-z

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