Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements
Milk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess differen...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-02-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-3921/2/1/23 |
| _version_ | 1797722606449721344 |
|---|---|
| author | Kevin Anthony Gitanjali Subramanya Susan Uprichard Faiza Hammouda Mahmoud Saleh |
| author_facet | Kevin Anthony Gitanjali Subramanya Susan Uprichard Faiza Hammouda Mahmoud Saleh |
| author_sort | Kevin Anthony |
| collection | DOAJ |
| description | Milk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess different brands of commercially sold silymarin, 45 products were collected from local stores and analyzed for their silymarin content, antioxidant activities, and antiviral activity against HCV. Antioxidant activity was measured as radical scavenging activity using DPPH and by estimating their antioxidant capacity as trolox equivalent. Anti-HCV activity was measured in an HCV genotype 1b replication inhibition assay. Samples were found to vary widely in their silymarin content, with some samples having none or very low concentrations while silymarin represented higher than 80% of other samples. Both antioxidant and anti-HCV activity correlated with the overall level of silymarin. |
| first_indexed | 2024-03-12T09:49:44Z |
| format | Article |
| id | doaj.art-18499bec0aae49ccb4eb555040ec359b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T09:49:44Z |
| publishDate | 2013-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-18499bec0aae49ccb4eb555040ec359b2023-09-02T12:34:12ZengMDPI AGAntioxidants2076-39212013-02-0121233610.3390/antiox2010023Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food SupplementsKevin AnthonyGitanjali SubramanyaSusan UprichardFaiza HammoudaMahmoud SalehMilk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess different brands of commercially sold silymarin, 45 products were collected from local stores and analyzed for their silymarin content, antioxidant activities, and antiviral activity against HCV. Antioxidant activity was measured as radical scavenging activity using DPPH and by estimating their antioxidant capacity as trolox equivalent. Anti-HCV activity was measured in an HCV genotype 1b replication inhibition assay. Samples were found to vary widely in their silymarin content, with some samples having none or very low concentrations while silymarin represented higher than 80% of other samples. Both antioxidant and anti-HCV activity correlated with the overall level of silymarin.http://www.mdpi.com/2076-3921/2/1/23Silybum marianumradical scavengerfood supplementover the counter drugshepatitis C virus |
| spellingShingle | Kevin Anthony Gitanjali Subramanya Susan Uprichard Faiza Hammouda Mahmoud Saleh Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements Antioxidants Silybum marianum radical scavenger food supplement over the counter drugs hepatitis C virus |
| title | Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements |
| title_full | Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements |
| title_fullStr | Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements |
| title_full_unstemmed | Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements |
| title_short | Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements |
| title_sort | antioxidant and anti hepatitis c viral activities of commercial milk thistle food supplements |
| topic | Silybum marianum radical scavenger food supplement over the counter drugs hepatitis C virus |
| url | http://www.mdpi.com/2076-3921/2/1/23 |
| work_keys_str_mv | AT kevinanthony antioxidantandantihepatitiscviralactivitiesofcommercialmilkthistlefoodsupplements AT gitanjalisubramanya antioxidantandantihepatitiscviralactivitiesofcommercialmilkthistlefoodsupplements AT susanuprichard antioxidantandantihepatitiscviralactivitiesofcommercialmilkthistlefoodsupplements AT faizahammouda antioxidantandantihepatitiscviralactivitiesofcommercialmilkthistlefoodsupplements AT mahmoudsaleh antioxidantandantihepatitiscviralactivitiesofcommercialmilkthistlefoodsupplements |