The emerging role of circadian rhythms in the development and function of thermogenic fat
Circadian rhythms regulate many biological processes in response to ambient influences. A disrupted circadian rhythm has been shown to be associated with obesity and obesity-related metabolic disorders. Thermogenic fat, including brown and beige fat, may play an important role in this process since...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1175845/full |
| _version_ | 1797821404192702464 |
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| author | Xuemin Peng Xuemin Peng Yong Chen Yong Chen Yong Chen |
| author_facet | Xuemin Peng Xuemin Peng Yong Chen Yong Chen Yong Chen |
| author_sort | Xuemin Peng |
| collection | DOAJ |
| description | Circadian rhythms regulate many biological processes in response to ambient influences. A disrupted circadian rhythm has been shown to be associated with obesity and obesity-related metabolic disorders. Thermogenic fat, including brown and beige fat, may play an important role in this process since it displays a high capacity to burn fat and release the stored energy as heat, contributing to the combat against obesity and its associated metabolic disorders. In this review, we summarize the relationship between the circadian clock and thermogenic fat and the prominent mechanisms which are involved in the regulation of the development and function of thermogenic fat by circadian rhythms, which may provide novel therapeutics for the prevention and treatment of metabolic diseases by targeting thermogenic fat in a circadian manner. |
| first_indexed | 2024-03-13T09:52:13Z |
| format | Article |
| id | doaj.art-184b25fc3948411eaca7c40fcf202dde |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T09:52:13Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-184b25fc3948411eaca7c40fcf202dde2023-05-24T06:10:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11758451175845The emerging role of circadian rhythms in the development and function of thermogenic fatXuemin Peng0Xuemin Peng1Yong Chen2Yong Chen3Yong Chen4Division of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaLaboratory of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaLaboratory of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaBranch of National Clinical Research Center for Metabolic Diseases, Hubei, ChinaCircadian rhythms regulate many biological processes in response to ambient influences. A disrupted circadian rhythm has been shown to be associated with obesity and obesity-related metabolic disorders. Thermogenic fat, including brown and beige fat, may play an important role in this process since it displays a high capacity to burn fat and release the stored energy as heat, contributing to the combat against obesity and its associated metabolic disorders. In this review, we summarize the relationship between the circadian clock and thermogenic fat and the prominent mechanisms which are involved in the regulation of the development and function of thermogenic fat by circadian rhythms, which may provide novel therapeutics for the prevention and treatment of metabolic diseases by targeting thermogenic fat in a circadian manner.https://www.frontiersin.org/articles/10.3389/fendo.2023.1175845/fullbrown/beige fatcircadian rhythmsobesitythermogenesiscircadian clock |
| spellingShingle | Xuemin Peng Xuemin Peng Yong Chen Yong Chen Yong Chen The emerging role of circadian rhythms in the development and function of thermogenic fat Frontiers in Endocrinology brown/beige fat circadian rhythms obesity thermogenesis circadian clock |
| title | The emerging role of circadian rhythms in the development and function of thermogenic fat |
| title_full | The emerging role of circadian rhythms in the development and function of thermogenic fat |
| title_fullStr | The emerging role of circadian rhythms in the development and function of thermogenic fat |
| title_full_unstemmed | The emerging role of circadian rhythms in the development and function of thermogenic fat |
| title_short | The emerging role of circadian rhythms in the development and function of thermogenic fat |
| title_sort | emerging role of circadian rhythms in the development and function of thermogenic fat |
| topic | brown/beige fat circadian rhythms obesity thermogenesis circadian clock |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1175845/full |
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