Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison
Background: Bacterial meningitis continues to be a global health problem even after introducing of meningococcal and pneumococcal vaccines. Surveillance of high-risk populations such as prisoners is necessary for timely identification of outbreaks and prophylaxis. This study assessed pharyngeal colo...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2023-05-01
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| Series: | Microbes and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mid.journals.ekb.eg/article_280810_1612d87ef1525f06f98613b1f4df25d0.pdf |
| _version_ | 1797827821314244608 |
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| author | Emmanuel Amewu Cynthia Adu-Asiamah Rawdat Baba-Adam Albert Afful Kennedy Gyau Alexander Kwarteng |
| author_facet | Emmanuel Amewu Cynthia Adu-Asiamah Rawdat Baba-Adam Albert Afful Kennedy Gyau Alexander Kwarteng |
| author_sort | Emmanuel Amewu |
| collection | DOAJ |
| description | Background: Bacterial meningitis continues to be a global health problem even after introducing of meningococcal and pneumococcal vaccines. Surveillance of high-risk populations such as prisoners is necessary for timely identification of outbreaks and prophylaxis. This study assessed pharyngeal colonisation of prisoners and officers in a Ghanaian prison with meningitis-causing bacteria. Methods: A cross-sectional study was conducted from January to April 2018. Oropharyngeal swabs were collected, and microbiological and antimicrobial susceptibility analyses were performed. Results: There were 205 participants. Carriage of meningitis-causing bacterial was 102 (49.7%), 8 (3.9%) and 1(0.48%) for Neisseria species (spp.), Staphylococcus aureus (S. aureus) and Streptococcus pneumoniae (S. pneumoniae), respectively and with a total carriage of 52.2% (107/ 205). Four individuals (1.9%) carried both Neisseria spp. and S. aureus. The S. aureus isolates were resistant to ampicillin (87.5%), chloramphenicol (87.5%), and penicillin (87.5%) and sensitive to cefoxitin (100%) cotrimoxazole (87.5%), clindamycin (87.5%), ciprofloxacin (75.0%), oxacillin (75.0%), and erythromycin (62.5%). None of the S. aureus isolated was methicillin resistant. The S. pneumoniae isolated was resistant to cotrimoxazole, tetracycline, and penicillin and sensitive to chloramphenicol, erythromycin, and clindamycin. Education (OR = 1.910, 95% CI 1.029 – 3.545, p < /em> = 0.040) and years of incarceration (OR = 3.808, 95% CI 1.350 – 10.739, p < /em> = 0.011) were associated with carriage of meningitis-causing bacteria. Conclusion: This study showed carriage of potential meningitis-causing bacteria in a Ghanaian prison. Multivalent meningococcal conjugate vaccine is key to controlling meningococcal disease outbreaks. |
| first_indexed | 2024-04-09T12:54:30Z |
| format | Article |
| id | doaj.art-184bb623f4224f5ab30218febaf47b41 |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-09T12:54:30Z |
| publishDate | 2023-05-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-184bb623f4224f5ab30218febaf47b412023-05-13T20:41:24ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402023-05-014248749610.21608/mid.2023.154583.1361280810Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prisonEmmanuel Amewu0Cynthia Adu-Asiamah1Rawdat Baba-Adam2Albert Afful3Kennedy Gyau4Alexander Kwarteng5Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, Ghana Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaKumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaDepartment of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, Ghana Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, GhanaBackground: Bacterial meningitis continues to be a global health problem even after introducing of meningococcal and pneumococcal vaccines. Surveillance of high-risk populations such as prisoners is necessary for timely identification of outbreaks and prophylaxis. This study assessed pharyngeal colonisation of prisoners and officers in a Ghanaian prison with meningitis-causing bacteria. Methods: A cross-sectional study was conducted from January to April 2018. Oropharyngeal swabs were collected, and microbiological and antimicrobial susceptibility analyses were performed. Results: There were 205 participants. Carriage of meningitis-causing bacterial was 102 (49.7%), 8 (3.9%) and 1(0.48%) for Neisseria species (spp.), Staphylococcus aureus (S. aureus) and Streptococcus pneumoniae (S. pneumoniae), respectively and with a total carriage of 52.2% (107/ 205). Four individuals (1.9%) carried both Neisseria spp. and S. aureus. The S. aureus isolates were resistant to ampicillin (87.5%), chloramphenicol (87.5%), and penicillin (87.5%) and sensitive to cefoxitin (100%) cotrimoxazole (87.5%), clindamycin (87.5%), ciprofloxacin (75.0%), oxacillin (75.0%), and erythromycin (62.5%). None of the S. aureus isolated was methicillin resistant. The S. pneumoniae isolated was resistant to cotrimoxazole, tetracycline, and penicillin and sensitive to chloramphenicol, erythromycin, and clindamycin. Education (OR = 1.910, 95% CI 1.029 – 3.545, p < /em> = 0.040) and years of incarceration (OR = 3.808, 95% CI 1.350 – 10.739, p < /em> = 0.011) were associated with carriage of meningitis-causing bacteria. Conclusion: This study showed carriage of potential meningitis-causing bacteria in a Ghanaian prison. Multivalent meningococcal conjugate vaccine is key to controlling meningococcal disease outbreaks.https://mid.journals.ekb.eg/article_280810_1612d87ef1525f06f98613b1f4df25d0.pdfpharyngealmeningitisneisseriaantimicrobial susceptibilityprison |
| spellingShingle | Emmanuel Amewu Cynthia Adu-Asiamah Rawdat Baba-Adam Albert Afful Kennedy Gyau Alexander Kwarteng Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison Microbes and Infectious Diseases pharyngeal meningitis neisseria antimicrobial susceptibility prison |
| title | Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison |
| title_full | Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison |
| title_fullStr | Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison |
| title_full_unstemmed | Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison |
| title_short | Oropharyngeal carriage of potential meningitis-causing bacteria in a Ghanaian prison |
| title_sort | oropharyngeal carriage of potential meningitis causing bacteria in a ghanaian prison |
| topic | pharyngeal meningitis neisseria antimicrobial susceptibility prison |
| url | https://mid.journals.ekb.eg/article_280810_1612d87ef1525f06f98613b1f4df25d0.pdf |
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