<i>PIK3R1</i><sup>W624R</sup> Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma

<i>PIK3R1</i><sup>W624R</sup> Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma

Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack biological or clinical validation. We fully characterized 43 lines of Patient-Derived Xenografts (PDXs) and performed copy number analysis and who...

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Bibliographic Details
Main Authors: Concetta D’Ambrosio, Jessica Erriquez, Maddalena Arigoni, Sonia Capellero, Gloria Mittica, Eleonora Ghisoni, Fulvio Borella, Dionyssios Katsaros, Silvana Privitera, Marisa Ribotta, Elena Maldi, Giovanna Di Nardo, Enrico Berrino, Tiziana Venesio, Riccardo Ponzone, Marco Vaira, Douglas Hall, Mercedes Jimenez-Linan, Anna L. Paterson, Raffaele A. Calogero, James D. Brenton, Giorgio Valabrega, Maria Flavia Di Renzo, Martina Olivero
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
ovarian cancer
pi3k
pik3r1
patient-derived xenografts
pdx derived tumour cells
Online Access:https://www.mdpi.com/2073-4409/9/2/442

Internet

https://www.mdpi.com/2073-4409/9/2/442

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