Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting
<b>Background:</b> CT-guided hook-wire localization is an essential step in the management of small pulmonary nodules. Few studies, however, have focused on reducing radiation exposure during the procedure. <b>Purpose:</b> This study aims to explore the feasibility of impleme...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/20/3235 |
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| author | Wei Wei Shi-Geng Wang Jing-Yi Zhang Xiao-Yu Togn Bei-Bei Li Xin Fang Ren-Wang Pu Yu-Jing Zhou Yi-Jun Liu |
| author_facet | Wei Wei Shi-Geng Wang Jing-Yi Zhang Xiao-Yu Togn Bei-Bei Li Xin Fang Ren-Wang Pu Yu-Jing Zhou Yi-Jun Liu |
| author_sort | Wei Wei |
| collection | DOAJ |
| description | <b>Background:</b> CT-guided hook-wire localization is an essential step in the management of small pulmonary nodules. Few studies, however, have focused on reducing radiation exposure during the procedure. <b>Purpose:</b> This study aims to explore the feasibility of implementing a low-dose computed tomography (CT)-guided hook wire localization using tailored kVp based on patients’ body size. <b>Materials and Methods:</b> A total of 151 patients with small pulmonary nodules were prospectively enrolled for CT-guided hook wire localization using individualized low-dose CT (LDCT) vs. standard-dose CT (SDCT) protocols. Radiation dose, image quality, characteristics of target nodules and procedure-related variables were compared. All variables were analyzed using Chi-Square and Student’s <i>t</i>-test. <b>Results:</b> The mean CTDIvol was significantly reduced for LDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 0.56 ± 0.00 mGy and for BMI > 21 kg/m<sup>2</sup>, 1.48 ± 0.00 mGy) when compared with SDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 5.24 ± 0.95 mGy and for BMI > 21 kg/m<sup>2</sup>, 6.69 ± 1.47 mGy). Accordingly, the DLP of LDCT was significantly reduced as compared with that of SDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 56.86 ± 4.73 vs. 533.58 ± 122.06 mGy.cm, and for BMI > 21 kg/m<sup>2</sup>, 167.02 ± 38.76 vs. 746.01 ± 230.91 mGy.cm). In comparison with SDCT, the effective dose (ED) of LDCT decreased by an average of 89.42% (for BMI ≤ 21 kg/m<sup>2</sup>) and 77.68% (for BMI > 21 kg/m<sup>2</sup>), respectively. Although the images acquired with the LDCT protocol yielded inferior quality to those acquired with the SDCT protocol, they were clinically acceptable for hook wire localization. <b>Conclusions:</b> LDCT-guided localization can provide safety and nodule detection performance comparable to SDCT-guided localization, benefiting radiation dose reduction dramatically, especially for patients with small body mass indexes. |
| first_indexed | 2024-03-10T21:18:17Z |
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| id | doaj.art-184e9f969829428c912efd887dd39cd0 |
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| spelling | doaj.art-184e9f969829428c912efd887dd39cd02023-11-19T16:13:13ZengMDPI AGDiagnostics2075-44182023-10-011320323510.3390/diagnostics13203235Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical SettingWei Wei0Shi-Geng Wang1Jing-Yi Zhang2Xiao-Yu Togn3Bei-Bei Li4Xin Fang5Ren-Wang Pu6Yu-Jing Zhou7Yi-Jun Liu8Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China<b>Background:</b> CT-guided hook-wire localization is an essential step in the management of small pulmonary nodules. Few studies, however, have focused on reducing radiation exposure during the procedure. <b>Purpose:</b> This study aims to explore the feasibility of implementing a low-dose computed tomography (CT)-guided hook wire localization using tailored kVp based on patients’ body size. <b>Materials and Methods:</b> A total of 151 patients with small pulmonary nodules were prospectively enrolled for CT-guided hook wire localization using individualized low-dose CT (LDCT) vs. standard-dose CT (SDCT) protocols. Radiation dose, image quality, characteristics of target nodules and procedure-related variables were compared. All variables were analyzed using Chi-Square and Student’s <i>t</i>-test. <b>Results:</b> The mean CTDIvol was significantly reduced for LDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 0.56 ± 0.00 mGy and for BMI > 21 kg/m<sup>2</sup>, 1.48 ± 0.00 mGy) when compared with SDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 5.24 ± 0.95 mGy and for BMI > 21 kg/m<sup>2</sup>, 6.69 ± 1.47 mGy). Accordingly, the DLP of LDCT was significantly reduced as compared with that of SDCT (for BMI ≤ 21 kg/m<sup>2</sup>, 56.86 ± 4.73 vs. 533.58 ± 122.06 mGy.cm, and for BMI > 21 kg/m<sup>2</sup>, 167.02 ± 38.76 vs. 746.01 ± 230.91 mGy.cm). In comparison with SDCT, the effective dose (ED) of LDCT decreased by an average of 89.42% (for BMI ≤ 21 kg/m<sup>2</sup>) and 77.68% (for BMI > 21 kg/m<sup>2</sup>), respectively. Although the images acquired with the LDCT protocol yielded inferior quality to those acquired with the SDCT protocol, they were clinically acceptable for hook wire localization. <b>Conclusions:</b> LDCT-guided localization can provide safety and nodule detection performance comparable to SDCT-guided localization, benefiting radiation dose reduction dramatically, especially for patients with small body mass indexes.https://www.mdpi.com/2075-4418/13/20/3235hook wirepulmonary nodulesradiation dosagetomographyX-ray computed |
| spellingShingle | Wei Wei Shi-Geng Wang Jing-Yi Zhang Xiao-Yu Togn Bei-Bei Li Xin Fang Ren-Wang Pu Yu-Jing Zhou Yi-Jun Liu Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting Diagnostics hook wire pulmonary nodules radiation dosage tomography X-ray computed |
| title | Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting |
| title_full | Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting |
| title_fullStr | Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting |
| title_full_unstemmed | Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting |
| title_short | Implementation of Individualized Low-Dose Computed Tomography-Guided Hook Wire Localization of Pulmonary Nodules: Feasibility and Safety in the Clinical Setting |
| title_sort | implementation of individualized low dose computed tomography guided hook wire localization of pulmonary nodules feasibility and safety in the clinical setting |
| topic | hook wire pulmonary nodules radiation dosage tomography X-ray computed |
| url | https://www.mdpi.com/2075-4418/13/20/3235 |
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