IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells

IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells

Previous studies infecting global IL-4Rα−/−, IL-4−/−, and IL-13−/−mice on a BALB/c background with the visceralizing parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4, and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequ...

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Bibliographic Details
Main Authors: Emma McFarlane, Thabang Mokgethi, Paul M. Kaye, Ramona Hurdayal, Frank Brombacher, James Alexander, Katharine C. Carter
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
Leishmania donovani
IL-4Rα
IL-4
T cell
mice
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01957/full

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