Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis
Background: Vitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene. Me...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-07-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763814000624 |
| _version_ | 1818330781226893312 |
|---|---|
| author | Aida Abdeen Mahmoud Abdellah Hamed Khalil Ali |
| author_facet | Aida Abdeen Mahmoud Abdellah Hamed Khalil Ali |
| author_sort | Aida Abdeen Mahmoud |
| collection | DOAJ |
| description | Background: Vitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene.
Methods: We conducted a case–control study to identify 25(OH) D levels and FOK1 polymorphism of the VDR gene in a group of newly diagnosed pulmonary TB patients and compared to the findings in a group of healthy controls.
Results: Obtained results revealed that 25(OH) D levels were significantly lower in the patients than in the controls (P < 0.0001), and the prevalence of vitamin D insufficiency was 72.5% in TB patients. The frequencies of FokI genotypes determined from TB patients were 30% for FF , 50% for Ff and 20% for ff, while in controls, the frequency of FF, Ff and ff were present in a percentage of; 40%, 40% and 20%, respectively. There was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism (P > 0.05). Also, no association between VDR genotype and 25(OH) D levels was found.
Conclusion: FokI polymorphisms in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in the Egyptian population. However, vitamin D deficiency may be a cause of the susceptibility to tuberculosis. |
| first_indexed | 2024-12-13T13:09:24Z |
| format | Article |
| id | doaj.art-184f15b0bf2947f1bb4ffb9e66395073 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-13T13:09:24Z |
| publishDate | 2014-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-184f15b0bf2947f1bb4ffb9e663950732022-12-21T23:44:43ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382014-07-0163365165510.1016/j.ejcdt.2014.02.015Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosisAida Abdeen Mahmoud0Abdellah Hamed Khalil Ali1Department of Biochemistry, Faculty of Medicine, Sohag University, EgyptDepartment of Respiratory Medicine, Faculty of Medicine, Sohag University, EgyptBackground: Vitamin D is a potent immunomodulator of innate immune responses, and its deficiency was implicated in the activation of tuberculosis (TB). The effects of vitamin D are exerted by the interaction with the vitamin D receptor (VDR) and may be influenced by polymorphisms in the VDR gene. Methods: We conducted a case–control study to identify 25(OH) D levels and FOK1 polymorphism of the VDR gene in a group of newly diagnosed pulmonary TB patients and compared to the findings in a group of healthy controls. Results: Obtained results revealed that 25(OH) D levels were significantly lower in the patients than in the controls (P < 0.0001), and the prevalence of vitamin D insufficiency was 72.5% in TB patients. The frequencies of FokI genotypes determined from TB patients were 30% for FF , 50% for Ff and 20% for ff, while in controls, the frequency of FF, Ff and ff were present in a percentage of; 40%, 40% and 20%, respectively. There was no significant association between the genotype groups, TB patient and normal control, for FokI polymorphism (P > 0.05). Also, no association between VDR genotype and 25(OH) D levels was found. Conclusion: FokI polymorphisms in the VDR gene do not appear to be responsible for host susceptibility to human tuberculosis in the Egyptian population. However, vitamin D deficiency may be a cause of the susceptibility to tuberculosis.http://www.sciencedirect.com/science/article/pii/S0422763814000624Vitamin DVitamin D receptorFokI genotypesTuberculosis |
| spellingShingle | Aida Abdeen Mahmoud Abdellah Hamed Khalil Ali Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis Egyptian Journal of Chest Disease and Tuberculosis Vitamin D Vitamin D receptor FokI genotypes Tuberculosis |
| title | Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis |
| title_full | Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis |
| title_fullStr | Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis |
| title_full_unstemmed | Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis |
| title_short | Vitamin D receptor gene polymorphism and 25 hydroxy vitamin D levels in Egyptian patients with pulmonary tuberculosis |
| title_sort | vitamin d receptor gene polymorphism and 25 hydroxy vitamin d levels in egyptian patients with pulmonary tuberculosis |
| topic | Vitamin D Vitamin D receptor FokI genotypes Tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S0422763814000624 |
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