Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

Single-Cell RNA-Seq Reveals Transcriptomic Heterogeneity and Post-Traumatic Osteoarthritis-Associated Early Molecular Changes in Mouse Articular Chondrocytes

Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally. The articular cartilage is composed of a dense extracellular matrix (ECM) with...

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Bibliographic Details
Main Authors: Aimy Sebastian, Jillian L. McCool, Nicholas R. Hum, Deepa K. Murugesh, Stephen P. Wilson, Blaine A. Christiansen, Gabriela G. Loots
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
osteoarthritis
chondrocyte heterogeneity
scRNA-seq
PTOA
cartilage
gene expression
Online Access:https://www.mdpi.com/2073-4409/10/6/1462

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