Serum level of vitamin A in febrile children with and without seizure: A comparative study
Objective: The role of vitamins and antioxidants in the febrile seizure (FS) has recently become of interest. The role of Vitamin A in seizure is remained controversial. It may suppress or provoke the seizure. In present study, the serum vitamin A level in febrile patients was compared with febrile...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023057444 |
| _version_ | 1797732976939761664 |
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| author | Elham Bakhtiari Farhad Heydarian Fatemeh Azmoudeh Maziyar Kaffashbashi Mohammad Heidarian |
| author_facet | Elham Bakhtiari Farhad Heydarian Fatemeh Azmoudeh Maziyar Kaffashbashi Mohammad Heidarian |
| author_sort | Elham Bakhtiari |
| collection | DOAJ |
| description | Objective: The role of vitamins and antioxidants in the febrile seizure (FS) has recently become of interest. The role of Vitamin A in seizure is remained controversial. It may suppress or provoke the seizure. In present study, the serum vitamin A level in febrile patients was compared with febrile seizure children for the first time. Method: In a cross-sectional study, eighty children aged 6–60 months including 40 febrile children and 40 children with FS were included. Blood samples were obtained, and the serum level of vitamin A and other blood parameters were measured. Results: Patients were similar in demographic characteristics (p = 0.06 for age and p = 0.41 for sex). The serum vitamin A level was 0.19 (0.12, 0.25) and 0.22 (0.17, 0.29) milligram per liter (mg/L) in febrile and FS group respectively (p = 0.33). In children aged less than 24 months the serum vitamin A level in FS and febrile group was 0.22 ± 0.07 and 0.24 ± 0.12 mg/L respectively (p = 0.56). In children aged more than 24 months the serum vitamin A level in FS group was higher significantly in comparison with febrile group (0.25 ± 0.11 and 0.16 ± 0.07 mg/L respectively, p = 0.01). Conclusion: Serum vitamin A level was not different in febrile children with and without seizure. Surprisingly in children aged more than 24 months, the serum level of vitamin A was higher in FS group than in the febrile children. More studies are needed to confirm the present observation. |
| first_indexed | 2024-03-12T12:22:19Z |
| format | Article |
| id | doaj.art-185064be647d4799bac8260b7d8570f3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:22:19Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-185064be647d4799bac8260b7d8570f32023-08-30T05:51:40ZengElsevierHeliyon2405-84402023-08-0198e18536Serum level of vitamin A in febrile children with and without seizure: A comparative studyElham Bakhtiari0Farhad Heydarian1Fatemeh Azmoudeh2Maziyar Kaffashbashi3Mohammad Heidarian4Eye Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author. Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pathology, University of lowa, lowa, IA, United StatesObjective: The role of vitamins and antioxidants in the febrile seizure (FS) has recently become of interest. The role of Vitamin A in seizure is remained controversial. It may suppress or provoke the seizure. In present study, the serum vitamin A level in febrile patients was compared with febrile seizure children for the first time. Method: In a cross-sectional study, eighty children aged 6–60 months including 40 febrile children and 40 children with FS were included. Blood samples were obtained, and the serum level of vitamin A and other blood parameters were measured. Results: Patients were similar in demographic characteristics (p = 0.06 for age and p = 0.41 for sex). The serum vitamin A level was 0.19 (0.12, 0.25) and 0.22 (0.17, 0.29) milligram per liter (mg/L) in febrile and FS group respectively (p = 0.33). In children aged less than 24 months the serum vitamin A level in FS and febrile group was 0.22 ± 0.07 and 0.24 ± 0.12 mg/L respectively (p = 0.56). In children aged more than 24 months the serum vitamin A level in FS group was higher significantly in comparison with febrile group (0.25 ± 0.11 and 0.16 ± 0.07 mg/L respectively, p = 0.01). Conclusion: Serum vitamin A level was not different in febrile children with and without seizure. Surprisingly in children aged more than 24 months, the serum level of vitamin A was higher in FS group than in the febrile children. More studies are needed to confirm the present observation.http://www.sciencedirect.com/science/article/pii/S2405844023057444ChildSeizureVitamin AFever |
| spellingShingle | Elham Bakhtiari Farhad Heydarian Fatemeh Azmoudeh Maziyar Kaffashbashi Mohammad Heidarian Serum level of vitamin A in febrile children with and without seizure: A comparative study Heliyon Child Seizure Vitamin A Fever |
| title | Serum level of vitamin A in febrile children with and without seizure: A comparative study |
| title_full | Serum level of vitamin A in febrile children with and without seizure: A comparative study |
| title_fullStr | Serum level of vitamin A in febrile children with and without seizure: A comparative study |
| title_full_unstemmed | Serum level of vitamin A in febrile children with and without seizure: A comparative study |
| title_short | Serum level of vitamin A in febrile children with and without seizure: A comparative study |
| title_sort | serum level of vitamin a in febrile children with and without seizure a comparative study |
| topic | Child Seizure Vitamin A Fever |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023057444 |
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