Current directions in searching for tuberculostatic substances
Yearly, 8 milion people advance to active tuberculosis (TB) and nearly 2 milion victims die of their infection. Long drug regimen is blamed for the emergence of drug resistant TB. Moreover, 20% of TB isolates are already resistant to the first line antituberculosis drugs. This situation has required...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Poznan University of Medical Sciences
2014-06-01
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| Series: | Journal of Medical Science |
| Subjects: | |
| Online Access: | https://jms.ump.edu.pl/index.php/JMS/article/view/58 |
| _version_ | 1818722335896633344 |
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| author | Justyna Żwawiak Lucjusz Zaprutko |
| author_facet | Justyna Żwawiak Lucjusz Zaprutko |
| author_sort | Justyna Żwawiak |
| collection | DOAJ |
| description | Yearly, 8 milion people advance to active tuberculosis (TB) and nearly 2 milion victims die of their infection. Long drug regimen is blamed for the emergence of drug resistant TB. Moreover, 20% of TB isolates are already resistant to the first line antituberculosis drugs. This situation has required to develop new, more active anti-TB substances. Several novel drug candidates from different groups of chemical compounds undergo clinical trials. Others, also promising agents, have been obtained recently. They are the basis for further modifications heading for improvement of their physicochemical, biological and toxicological parameters. |
| first_indexed | 2024-12-17T20:53:00Z |
| format | Article |
| id | doaj.art-1851030876904c9eb275877dcd1f0e04 |
| institution | Directory Open Access Journal |
| issn | 2353-9798 2353-9801 |
| language | English |
| last_indexed | 2024-12-17T20:53:00Z |
| publishDate | 2014-06-01 |
| publisher | Poznan University of Medical Sciences |
| record_format | Article |
| series | Journal of Medical Science |
| spelling | doaj.art-1851030876904c9eb275877dcd1f0e042022-12-21T21:32:58ZengPoznan University of Medical SciencesJournal of Medical Science2353-97982353-98012014-06-0183210.20883/medical.e58Current directions in searching for tuberculostatic substancesJustyna Żwawiak0Lucjusz Zaprutko1Department of Organic Chemistry, Poznan University of Medical Sciences, PolandDepartment of Organic Chemistry, Poznan University of Medical Sciences, PolandYearly, 8 milion people advance to active tuberculosis (TB) and nearly 2 milion victims die of their infection. Long drug regimen is blamed for the emergence of drug resistant TB. Moreover, 20% of TB isolates are already resistant to the first line antituberculosis drugs. This situation has required to develop new, more active anti-TB substances. Several novel drug candidates from different groups of chemical compounds undergo clinical trials. Others, also promising agents, have been obtained recently. They are the basis for further modifications heading for improvement of their physicochemical, biological and toxicological parameters.https://jms.ump.edu.pl/index.php/JMS/article/view/58tuberculosistuberculostatic agentsclinical trials |
| spellingShingle | Justyna Żwawiak Lucjusz Zaprutko Current directions in searching for tuberculostatic substances Journal of Medical Science tuberculosis tuberculostatic agents clinical trials |
| title | Current directions in searching for tuberculostatic substances |
| title_full | Current directions in searching for tuberculostatic substances |
| title_fullStr | Current directions in searching for tuberculostatic substances |
| title_full_unstemmed | Current directions in searching for tuberculostatic substances |
| title_short | Current directions in searching for tuberculostatic substances |
| title_sort | current directions in searching for tuberculostatic substances |
| topic | tuberculosis tuberculostatic agents clinical trials |
| url | https://jms.ump.edu.pl/index.php/JMS/article/view/58 |
| work_keys_str_mv | AT justynazwawiak currentdirectionsinsearchingfortuberculostaticsubstances AT lucjuszzaprutko currentdirectionsinsearchingfortuberculostaticsubstances |