Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021
Geremew Tsegaye,1 Yenealem Gezahegn,2 Assegid Tesfaye,1 Gadissa Mulatu,3 Gemechu Gudina Bulcha,4 Naod Berhanu5 1Ethiopian Field Epidemiology and Laboratory Training Program, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 2Department of Epidemiology, Faculty of Public Health, Jimma Univ...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/measles-outbreak-investigation-in-guradamole-district-of-bale-zone-sou-peer-reviewed-fulltext-article-IDR |
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| author | Tsegaye G Gezahegn Y Tesfaye A Mulatu G Bulcha GG Berhanu N |
| author_facet | Tsegaye G Gezahegn Y Tesfaye A Mulatu G Bulcha GG Berhanu N |
| author_sort | Tsegaye G |
| collection | DOAJ |
| description | Geremew Tsegaye,1 Yenealem Gezahegn,2 Assegid Tesfaye,1 Gadissa Mulatu,3 Gemechu Gudina Bulcha,4 Naod Berhanu5 1Ethiopian Field Epidemiology and Laboratory Training Program, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 2Department of Epidemiology, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 3Disease Control and Prevention Department, Bale Zone Health Office, Robe, Ethiopia; 4Public Health Emergency Management Department, Oromia Regional Health Bureau, Addis Ababa, Ethiopia; 5Field Epidemiology, Department of Epidemiology, Faculty of Public Health, Jimma University, Jimma, EthiopiaCorrespondence: Geremew Tsegaye, Ethiopian Field Epidemiology and Laboratory Training Program, Faculty of Public Health, Jimma University, Jimma, Ethiopia, Email garamuts0606@gmail.comBackground: Measles is a highly contagious viral illness and globally, 142,300 people died from measles in 2018. On 25 March 2021, an outbreak of measles was reported from Guradamole district Bale Zone Southeast Ethiopia. Hence, we investigated to determine existence of the outbreak and to identify the associated factors.Method: Descriptive and 1:2 unmatched case–control study was done in Guradamole district from March 25 to April 9/2021. For the descriptive study, a total of 98 cases were used. To identify the factor associated with the outbreak, 60 cases were selected by computer-generated simple random method by using line list as a sampling frame and 120 controls were studied. Active cases were identified through home-to-home searching in affected kebeles and controls were selected from neighbors of cases. Five serum samples were taken and an IgM test was done to confirm cases. Cases were any person who developed fever, maculopapular rash and cough, coryza or conjunctivitis while controls were without such diagnosis. We collected data by using a structured questionnaire, cases were described by time, place, and person; logistic regression was used to identify factors associated with measles. In the multivariable analysis P-value < 0.05 was declared statistical significance.Results: Overall, 98 cases were identified with an overall attack rate of 12/1000 population and a case fatality rate (CFR) of 7%. The highest attack rate (38/1000 population) and CFR (57%) were among children aged < 59 months. Vaccination efficacy was calculated to be 82.6%. Being unvaccinated (adjusted odds ratio/AOR=5.66, 95% confidence interval, CI: 1.24– 25.81), contact with patient (AOR=3.24, 95%CI: 1.03– 10.17), moderate malnutrition (AOR=4.34, 95%CI: 2.14– 8.814), distance from health facility (AOR=4.58, 95%CI: 1.39– 15.19) and history of travel to affected area (AOR=3.99, 95%CI: 1.31– 12.19) were shown significant associated with measles infection.Conclusion: The attack and fatality rate of the investigation were high. Being unvaccinated, distant from the health facility, malnutrition, and history of contact with measles case were associated with the outbreak. We recommend conducting vaccination campaigns, interventions to malnutrition, and strengthening routine immunization programs to reduce future measles outbreaks.Keywords: measles, outbreak, Guradamole, Bale, Ethiopia |
| first_indexed | 2024-12-20T18:27:38Z |
| format | Article |
| id | doaj.art-1851bab5da314ecf98efb9c5ac379d56 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-20T18:27:38Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-1851bab5da314ecf98efb9c5ac379d562022-12-21T19:30:06ZengDove Medical PressInfection and Drug Resistance1178-69732022-02-01Volume 1566968373270Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021Tsegaye GGezahegn YTesfaye AMulatu GBulcha GGBerhanu NGeremew Tsegaye,1 Yenealem Gezahegn,2 Assegid Tesfaye,1 Gadissa Mulatu,3 Gemechu Gudina Bulcha,4 Naod Berhanu5 1Ethiopian Field Epidemiology and Laboratory Training Program, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 2Department of Epidemiology, Faculty of Public Health, Jimma University, Jimma, Ethiopia; 3Disease Control and Prevention Department, Bale Zone Health Office, Robe, Ethiopia; 4Public Health Emergency Management Department, Oromia Regional Health Bureau, Addis Ababa, Ethiopia; 5Field Epidemiology, Department of Epidemiology, Faculty of Public Health, Jimma University, Jimma, EthiopiaCorrespondence: Geremew Tsegaye, Ethiopian Field Epidemiology and Laboratory Training Program, Faculty of Public Health, Jimma University, Jimma, Ethiopia, Email garamuts0606@gmail.comBackground: Measles is a highly contagious viral illness and globally, 142,300 people died from measles in 2018. On 25 March 2021, an outbreak of measles was reported from Guradamole district Bale Zone Southeast Ethiopia. Hence, we investigated to determine existence of the outbreak and to identify the associated factors.Method: Descriptive and 1:2 unmatched case–control study was done in Guradamole district from March 25 to April 9/2021. For the descriptive study, a total of 98 cases were used. To identify the factor associated with the outbreak, 60 cases were selected by computer-generated simple random method by using line list as a sampling frame and 120 controls were studied. Active cases were identified through home-to-home searching in affected kebeles and controls were selected from neighbors of cases. Five serum samples were taken and an IgM test was done to confirm cases. Cases were any person who developed fever, maculopapular rash and cough, coryza or conjunctivitis while controls were without such diagnosis. We collected data by using a structured questionnaire, cases were described by time, place, and person; logistic regression was used to identify factors associated with measles. In the multivariable analysis P-value < 0.05 was declared statistical significance.Results: Overall, 98 cases were identified with an overall attack rate of 12/1000 population and a case fatality rate (CFR) of 7%. The highest attack rate (38/1000 population) and CFR (57%) were among children aged < 59 months. Vaccination efficacy was calculated to be 82.6%. Being unvaccinated (adjusted odds ratio/AOR=5.66, 95% confidence interval, CI: 1.24– 25.81), contact with patient (AOR=3.24, 95%CI: 1.03– 10.17), moderate malnutrition (AOR=4.34, 95%CI: 2.14– 8.814), distance from health facility (AOR=4.58, 95%CI: 1.39– 15.19) and history of travel to affected area (AOR=3.99, 95%CI: 1.31– 12.19) were shown significant associated with measles infection.Conclusion: The attack and fatality rate of the investigation were high. Being unvaccinated, distant from the health facility, malnutrition, and history of contact with measles case were associated with the outbreak. We recommend conducting vaccination campaigns, interventions to malnutrition, and strengthening routine immunization programs to reduce future measles outbreaks.Keywords: measles, outbreak, Guradamole, Bale, Ethiopiahttps://www.dovepress.com/measles-outbreak-investigation-in-guradamole-district-of-bale-zone-sou-peer-reviewed-fulltext-article-IDRmeaslesoutbreakguradamolebale ethiopia |
| spellingShingle | Tsegaye G Gezahegn Y Tesfaye A Mulatu G Bulcha GG Berhanu N Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 Infection and Drug Resistance measles outbreak guradamole bale ethiopia |
| title | Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 |
| title_full | Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 |
| title_fullStr | Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 |
| title_full_unstemmed | Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 |
| title_short | Measles Outbreak Investigation in Guradamole District of Bale Zone, South Eastern Ethiopia, 2021 |
| title_sort | measles outbreak investigation in guradamole district of bale zone south eastern ethiopia 2021 |
| topic | measles outbreak guradamole bale ethiopia |
| url | https://www.dovepress.com/measles-outbreak-investigation-in-guradamole-district-of-bale-zone-sou-peer-reviewed-fulltext-article-IDR |
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