Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies

Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies

Background: Cyclic nucleotides are second messengers, which play significant roles in numerous biological processes. Previous work has shown that cAMP and cGMP signaling regulates various pathways in liver cells, including Kupffer cells, hepatocytes, hepatic stellate cells, and cellular components o...

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Bibliographic Details
Main Authors: Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H. Chariker, Eric C. Rouchka, Claudio Maldonado, Shirish Barve, Craig J. McClain, Leila Gobejishvili
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biology
Subjects:
alcohol-associated steatohepatitis
liver
cAMP
cGMP
phosphodiesterases
Online Access:https://www.mdpi.com/2079-7737/12/10/1321

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