Comparison of Four fMRI Paradigms Probing Emotion Processing
Previous fMRI research has applied a variety of tasks to examine brain activity underlying emotion processing. While task characteristics are known to have a substantial influence on the elicited activations, direct comparisons of tasks that could guide study planning are scarce. We aimed to provide...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/5/525 |
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| author | Corinna Hartling Sophie Metz Corinna Pehrs Milan Scheidegger Rebecca Gruzman Christian Keicher Andreas Wunder Anne Weigand Simone Grimm |
| author_facet | Corinna Hartling Sophie Metz Corinna Pehrs Milan Scheidegger Rebecca Gruzman Christian Keicher Andreas Wunder Anne Weigand Simone Grimm |
| author_sort | Corinna Hartling |
| collection | DOAJ |
| description | Previous fMRI research has applied a variety of tasks to examine brain activity underlying emotion processing. While task characteristics are known to have a substantial influence on the elicited activations, direct comparisons of tasks that could guide study planning are scarce. We aimed to provide a comparison of four common emotion processing tasks based on the same analysis pipeline to suggest tasks best suited for the study of certain target brain regions. We studied an n-back task using emotional words (EMOBACK) as well as passive viewing tasks of emotional faces (FACES) and emotional scenes (OASIS and IAPS). We compared the activation patterns elicited by these tasks in four regions of interest (the amygdala, anterior insula, dorsolateral prefrontal cortex (dlPFC) and pregenual anterior cingulate cortex (pgACC)) in three samples of healthy adults (N = 45). The EMOBACK task elicited activation in the right dlPFC and bilateral anterior insula and deactivation in the pgACC while the FACES task recruited the bilateral amygdala. The IAPS and OASIS tasks showed similar activation patterns recruiting the bilateral amygdala and anterior insula. We conclude that these tasks can be used to study different regions involved in emotion processing and that the information provided is valuable for future research and the development of fMRI biomarkers. |
| first_indexed | 2024-03-10T12:05:24Z |
| format | Article |
| id | doaj.art-1856ff4e15984086bc4fdb27533032a1 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T12:05:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1856ff4e15984086bc4fdb27533032a12023-11-21T16:34:57ZengMDPI AGBrain Sciences2076-34252021-04-0111552510.3390/brainsci11050525Comparison of Four fMRI Paradigms Probing Emotion ProcessingCorinna Hartling0Sophie Metz1Corinna Pehrs2Milan Scheidegger3Rebecca Gruzman4Christian Keicher5Andreas Wunder6Anne Weigand7Simone Grimm8Department of Psychiatry and Psychotherapy, CBF, Charité Universitätsmedizin Berlin, 12203 Berlin, GermanyDepartment of Psychiatry and Psychotherapy, CBF, Charité Universitätsmedizin Berlin, 12203 Berlin, GermanyBernstein Center for Computational Neuroscience, Humboldt-University Berlin, 10115 Berlin, GermanyDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, 8032 Zurich, SwitzerlandDepartment of Psychiatry and Psychotherapy, CBF, Charité Universitätsmedizin Berlin, 12203 Berlin, GermanyCharité Research Organisation GmbH, 10117 Berlin, GermanyTranslational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH and Co. KG, 52216 Ingelheim am Rhein, GermanyDepartment of Psychology, Medical School Berlin, 14197 Berlin, GermanyDepartment of Psychiatry and Psychotherapy, CBF, Charité Universitätsmedizin Berlin, 12203 Berlin, GermanyPrevious fMRI research has applied a variety of tasks to examine brain activity underlying emotion processing. While task characteristics are known to have a substantial influence on the elicited activations, direct comparisons of tasks that could guide study planning are scarce. We aimed to provide a comparison of four common emotion processing tasks based on the same analysis pipeline to suggest tasks best suited for the study of certain target brain regions. We studied an n-back task using emotional words (EMOBACK) as well as passive viewing tasks of emotional faces (FACES) and emotional scenes (OASIS and IAPS). We compared the activation patterns elicited by these tasks in four regions of interest (the amygdala, anterior insula, dorsolateral prefrontal cortex (dlPFC) and pregenual anterior cingulate cortex (pgACC)) in three samples of healthy adults (N = 45). The EMOBACK task elicited activation in the right dlPFC and bilateral anterior insula and deactivation in the pgACC while the FACES task recruited the bilateral amygdala. The IAPS and OASIS tasks showed similar activation patterns recruiting the bilateral amygdala and anterior insula. We conclude that these tasks can be used to study different regions involved in emotion processing and that the information provided is valuable for future research and the development of fMRI biomarkers.https://www.mdpi.com/2076-3425/11/5/525fMRI paradigmsemotion processingamygdalaanterior insulapregenual ACC |
| spellingShingle | Corinna Hartling Sophie Metz Corinna Pehrs Milan Scheidegger Rebecca Gruzman Christian Keicher Andreas Wunder Anne Weigand Simone Grimm Comparison of Four fMRI Paradigms Probing Emotion Processing Brain Sciences fMRI paradigms emotion processing amygdala anterior insula pregenual ACC |
| title | Comparison of Four fMRI Paradigms Probing Emotion Processing |
| title_full | Comparison of Four fMRI Paradigms Probing Emotion Processing |
| title_fullStr | Comparison of Four fMRI Paradigms Probing Emotion Processing |
| title_full_unstemmed | Comparison of Four fMRI Paradigms Probing Emotion Processing |
| title_short | Comparison of Four fMRI Paradigms Probing Emotion Processing |
| title_sort | comparison of four fmri paradigms probing emotion processing |
| topic | fMRI paradigms emotion processing amygdala anterior insula pregenual ACC |
| url | https://www.mdpi.com/2076-3425/11/5/525 |
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