Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration
Receptor tyrosine kinases (RTKs) are known to perform versatile roles in disease landscapes, which determine the fate of the cell. Although much has been discussed from the perspective of proliferation, this review focuses on the impact of RTK-mediated signaling and its role in cytoskeletal degradat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2024-02-01
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| Series: | Exploration of Neuroscience |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/en/Article/100633 |
| _version_ | 1797301637613617152 |
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| author | Priyanka Sengupta Russa Das Piyali Majumder Debashis Mukhopadhyay |
| author_facet | Priyanka Sengupta Russa Das Piyali Majumder Debashis Mukhopadhyay |
| author_sort | Priyanka Sengupta |
| collection | DOAJ |
| description | Receptor tyrosine kinases (RTKs) are known to perform versatile roles in disease landscapes, which determine the fate of the cell. Although much has been discussed from the perspective of proliferation, this review focuses on the impact of RTK-mediated signaling and its role in cytoskeletal degradation, the penultimate stage of cellular degeneration. In the case of degenerative diseases such as Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), age-related macular degeneration (AMD), and type 2 diabetes mellitus (T2DM), RTK signaling has been reported to be perturbed in several studies. The implications of downstream signaling via these receptors through canonical and noncanonical pathways alter the status of actin filaments that provide structural integrity to cells. Degenerative signaling leads to the altered status of rat sarcoma (Ras), Ras homologous (Rho), Ras-related C3 botulinum toxin substrate (Rac), and cell division control protein 42 (Cdc42), the best-characterized components of the cytoskeleton remodeling machinery. RTKs, along with their diverse adaptor partners and other membrane receptors, affect the functionality of Rho family guanosine triphosphate hydrolases (GTPases), which are discussed in this review. To conclude, this review focuses on therapeutic strategies targeting RTKs and Rho GTPase-mediated pathways that can be more effective due to their combined multifactorial impact on neurodegenerative cascades. |
| first_indexed | 2024-03-07T23:24:30Z |
| format | Article |
| id | doaj.art-185711b52df24417ba7bbd4335623731 |
| institution | Directory Open Access Journal |
| issn | 2834-5347 |
| language | English |
| last_indexed | 2024-03-07T23:24:30Z |
| publishDate | 2024-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroscience |
| spelling | doaj.art-185711b52df24417ba7bbd43356237312024-02-21T05:07:14ZengOpen Exploration Publishing Inc.Exploration of Neuroscience2834-53472024-02-013112610.37349/en.2024.00033Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegenerationPriyanka Sengupta0https://orcid.org/0009-0003-9661-6992Russa Das1https://orcid.org/0009-0002-8212-253XPiyali Majumder2https://orcid.org/0000-0002-6538-9315Debashis Mukhopadhyay3https://orcid.org/0000-0002-4516-2260Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, A CI of Homi Bhabha National Institute, Kolkata 700064, IndiaBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, A CI of Homi Bhabha National Institute, Kolkata 700064, IndiaChemistry Department, Indian Institute of Technology Bombay, Maharashtra 400076, IndiaBiophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, A CI of Homi Bhabha National Institute, Kolkata 700064, IndiaReceptor tyrosine kinases (RTKs) are known to perform versatile roles in disease landscapes, which determine the fate of the cell. Although much has been discussed from the perspective of proliferation, this review focuses on the impact of RTK-mediated signaling and its role in cytoskeletal degradation, the penultimate stage of cellular degeneration. In the case of degenerative diseases such as Alzheimer’s disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), age-related macular degeneration (AMD), and type 2 diabetes mellitus (T2DM), RTK signaling has been reported to be perturbed in several studies. The implications of downstream signaling via these receptors through canonical and noncanonical pathways alter the status of actin filaments that provide structural integrity to cells. Degenerative signaling leads to the altered status of rat sarcoma (Ras), Ras homologous (Rho), Ras-related C3 botulinum toxin substrate (Rac), and cell division control protein 42 (Cdc42), the best-characterized components of the cytoskeleton remodeling machinery. RTKs, along with their diverse adaptor partners and other membrane receptors, affect the functionality of Rho family guanosine triphosphate hydrolases (GTPases), which are discussed in this review. To conclude, this review focuses on therapeutic strategies targeting RTKs and Rho GTPase-mediated pathways that can be more effective due to their combined multifactorial impact on neurodegenerative cascades.https://www.explorationpub.com/Journals/en/Article/100633receptor tyrosine kinase signalingnuclear translocationcytoskeletal remodelingcrosstalkrho gtpasesneurodegenerationrho/rac/cdc42 |
| spellingShingle | Priyanka Sengupta Russa Das Piyali Majumder Debashis Mukhopadhyay Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration Exploration of Neuroscience receptor tyrosine kinase signaling nuclear translocation cytoskeletal remodeling crosstalk rho gtpases neurodegeneration rho/rac/cdc42 |
| title | Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| title_full | Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| title_fullStr | Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| title_full_unstemmed | Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| title_short | Connecting the ends: signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| title_sort | connecting the ends signaling via receptor tyrosine kinases and cytoskeletal degradation in neurodegeneration |
| topic | receptor tyrosine kinase signaling nuclear translocation cytoskeletal remodeling crosstalk rho gtpases neurodegeneration rho/rac/cdc42 |
| url | https://www.explorationpub.com/Journals/en/Article/100633 |
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