Is Long COVID a State of Systemic Pericyte Disarray?
The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/3/572 |
| _version_ | 1797487010541207552 |
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| author | Olcay Y. Jones Sencer Yeralan |
| author_facet | Olcay Y. Jones Sencer Yeralan |
| author_sort | Olcay Y. Jones |
| collection | DOAJ |
| description | The most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with “Triple-A” qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies. |
| first_indexed | 2024-03-09T23:41:32Z |
| format | Article |
| id | doaj.art-1857eb8185154e8eb3c67e1ef75f7831 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:41:32Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1857eb8185154e8eb3c67e1ef75f78312023-11-23T16:50:34ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111357210.3390/jcm11030572Is Long COVID a State of Systemic Pericyte Disarray?Olcay Y. Jones0Sencer Yeralan1Pediatric Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD 20889, USASchool of IT and Engineering, ADA University, Baku AZ1008, AzerbaijanThe most challenging aspect of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) or Long COVID remains for the discordance between the viral damage from acute infection in the recent past and susceptibility of Long COVID without clear evidence of post infectious inflammation or autoimmune reactions. In this communication we propose that disarray of pericytes plays a central role in emerge of Long COVID. We assume pericytes are agents with “Triple-A” qualities, i.e., analyze-adapt and advance, necessary for sustainability of host homeostasis. Based on this view, we further suggest Long COVID may provide a model system to integrate system theory and complex adaptive systems to explore a new class of maladies those are currently not well defined and with no remedies.https://www.mdpi.com/2077-0383/11/3/572Long COVIDpericyteTriple-Acomplex dynamical systemsentropyemergent systems intelligence |
| spellingShingle | Olcay Y. Jones Sencer Yeralan Is Long COVID a State of Systemic Pericyte Disarray? Journal of Clinical Medicine Long COVID pericyte Triple-A complex dynamical systems entropy emergent systems intelligence |
| title | Is Long COVID a State of Systemic Pericyte Disarray? |
| title_full | Is Long COVID a State of Systemic Pericyte Disarray? |
| title_fullStr | Is Long COVID a State of Systemic Pericyte Disarray? |
| title_full_unstemmed | Is Long COVID a State of Systemic Pericyte Disarray? |
| title_short | Is Long COVID a State of Systemic Pericyte Disarray? |
| title_sort | is long covid a state of systemic pericyte disarray |
| topic | Long COVID pericyte Triple-A complex dynamical systems entropy emergent systems intelligence |
| url | https://www.mdpi.com/2077-0383/11/3/572 |
| work_keys_str_mv | AT olcayyjones islongcovidastateofsystemicpericytedisarray AT senceryeralan islongcovidastateofsystemicpericytedisarray |