A Review on Bioactivities of Tobacco Cembranoid Diterpenes
Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cem...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-01-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-273X/9/1/30 |
| _version_ | 1819151196596731904 |
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| author | Ning Yan Yongmei Du Xinmin Liu Hongbo Zhang Yanhua Liu Zhongfeng Zhang |
| author_facet | Ning Yan Yongmei Du Xinmin Liu Hongbo Zhang Yanhua Liu Zhongfeng Zhang |
| author_sort | Ning Yan |
| collection | DOAJ |
| description | Cembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships. |
| first_indexed | 2024-12-22T14:29:33Z |
| format | Article |
| id | doaj.art-18590d689a4d4b05a9e7cf6ff25ca88b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-22T14:29:33Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-18590d689a4d4b05a9e7cf6ff25ca88b2022-12-21T18:22:47ZengMDPI AGBiomolecules2218-273X2019-01-01913010.3390/biom9010030biom9010030A Review on Bioactivities of Tobacco Cembranoid DiterpenesNing Yan0Yongmei Du1Xinmin Liu2Hongbo Zhang3Yanhua Liu4Zhongfeng Zhang5Tobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaTobacco Research Institute of Chinese Academy of Agricultural Sciences, Qingdao 266101, ChinaCembranoids are carbocyclic diterpenes comprising four isoprene units and are natural products with a parent skeleton consisting of a 14-membered ring. They have gained wide interest in recent years and are a major hotspot in the research of natural product chemistry. Since 1962, various tobacco cembranoid diterpenes have been identified. This review systematically discusses and summarises the excellent antimicrobial, insecticidal, cytotoxic and neuroprotective activities of tobacco cembranoid diterpenes. These compounds show potential to be developed as botanical fungicides, cytotoxic drugs and drugs for the treatment of human immunodeficiency virus, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. However, there are relatively few studies on the structure–activity relationship (SAR) of tobacco cembranoid diterpenes. Therefore, future studies should focus on their structural modification, SAR and biogenic relationships.http://www.mdpi.com/2218-273X/9/1/30tobaccocembranoid diterpenesbioactivitybiocatalysissemisynthesis |
| spellingShingle | Ning Yan Yongmei Du Xinmin Liu Hongbo Zhang Yanhua Liu Zhongfeng Zhang A Review on Bioactivities of Tobacco Cembranoid Diterpenes Biomolecules tobacco cembranoid diterpenes bioactivity biocatalysis semisynthesis |
| title | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
| title_full | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
| title_fullStr | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
| title_full_unstemmed | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
| title_short | A Review on Bioactivities of Tobacco Cembranoid Diterpenes |
| title_sort | review on bioactivities of tobacco cembranoid diterpenes |
| topic | tobacco cembranoid diterpenes bioactivity biocatalysis semisynthesis |
| url | http://www.mdpi.com/2218-273X/9/1/30 |
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