Podoplanin: Its roles and functions in neurological diseases and brain cancers
Podoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in different cell types including choroid plexus...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.964973/full |
| _version_ | 1798001048918425600 |
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| author | Yi Wang Dan Peng Yaqian Huang Yongjun Cao Hui Li Xia Zhang |
| author_facet | Yi Wang Dan Peng Yaqian Huang Yongjun Cao Hui Li Xia Zhang |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | Podoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in different cell types including choroid plexus epithelial cells, glial cells, as well as periphery infiltrated immune cells during brain development and neurological disorders. As a transmembrane protein, podoplanin interacts with other molecules in the same or neighboring cells. In the past, a lot of studies reported a pleiotropic role of podoplanin in the modulation of thrombosis, inflammation, lymphangiogenesis, angiogenesis, immune surveillance, epithelial mesenchymal transition, as well as extracellular matrix remodeling in periphery, which have been well summarized and discussed. Recently, mounting evidence demonstrates the distribution and function of this molecule in brain development and neurological disorders. In this review, we summarize the research progresses in understanding the roles and mechanisms of podoplanin in the development and disorders of the nervous system. The challenges of podoplanin-targeted approaches for disease prognosis and preventions are also discussed. |
| first_indexed | 2024-04-11T11:29:58Z |
| format | Article |
| id | doaj.art-185a17cd823d4ffeb035bd737258a22c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T11:29:58Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-185a17cd823d4ffeb035bd737258a22c2022-12-22T04:26:10ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.964973964973Podoplanin: Its roles and functions in neurological diseases and brain cancersYi Wang0Dan Peng1Yaqian Huang2Yongjun Cao3Hui Li4Xia Zhang5Department of Neurology, The Second Affiliated Hospital of Soochow University and Clinical Research Center of Neurological Disease, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University and Clinical Research Center of Neurological Disease, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University and Clinical Research Center of Neurological Disease, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University and Clinical Research Center of Neurological Disease, Suzhou, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital of Soochow University and Clinical Research Center of Neurological Disease, Suzhou, ChinaPodoplanin is a small mucin-like glycoprotein involved in several physiological and pathological processes in the brain including development, angiogenesis, tumors, ischemic stroke and other neurological disorders. Podoplanin expression is upregulated in different cell types including choroid plexus epithelial cells, glial cells, as well as periphery infiltrated immune cells during brain development and neurological disorders. As a transmembrane protein, podoplanin interacts with other molecules in the same or neighboring cells. In the past, a lot of studies reported a pleiotropic role of podoplanin in the modulation of thrombosis, inflammation, lymphangiogenesis, angiogenesis, immune surveillance, epithelial mesenchymal transition, as well as extracellular matrix remodeling in periphery, which have been well summarized and discussed. Recently, mounting evidence demonstrates the distribution and function of this molecule in brain development and neurological disorders. In this review, we summarize the research progresses in understanding the roles and mechanisms of podoplanin in the development and disorders of the nervous system. The challenges of podoplanin-targeted approaches for disease prognosis and preventions are also discussed.https://www.frontiersin.org/articles/10.3389/fphar.2022.964973/fullpodoplaninClec-2thrombosisinflammationangiogenesisimmune response |
| spellingShingle | Yi Wang Dan Peng Yaqian Huang Yongjun Cao Hui Li Xia Zhang Podoplanin: Its roles and functions in neurological diseases and brain cancers Frontiers in Pharmacology podoplanin Clec-2 thrombosis inflammation angiogenesis immune response |
| title | Podoplanin: Its roles and functions in neurological diseases and brain cancers |
| title_full | Podoplanin: Its roles and functions in neurological diseases and brain cancers |
| title_fullStr | Podoplanin: Its roles and functions in neurological diseases and brain cancers |
| title_full_unstemmed | Podoplanin: Its roles and functions in neurological diseases and brain cancers |
| title_short | Podoplanin: Its roles and functions in neurological diseases and brain cancers |
| title_sort | podoplanin its roles and functions in neurological diseases and brain cancers |
| topic | podoplanin Clec-2 thrombosis inflammation angiogenesis immune response |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.964973/full |
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