Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation
Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate i...
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MDPI AG
2020-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/10/3207 |
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| author | Kerstin Dürholz Jörg Hofmann Aida Iljazovic Julian Häger Sébastien Lucas Kerstin Sarter Till Strowig Holger Bang Jürgen Rech Georg Schett Mario M. Zaiss |
| author_facet | Kerstin Dürholz Jörg Hofmann Aida Iljazovic Julian Häger Sébastien Lucas Kerstin Sarter Till Strowig Holger Bang Jürgen Rech Georg Schett Mario M. Zaiss |
| author_sort | Kerstin Dürholz |
| collection | DOAJ |
| description | Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls (<i>n</i> = 10) and RA patients (<i>n</i> = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro- and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies. |
| first_indexed | 2024-03-10T15:28:18Z |
| format | Article |
| id | doaj.art-185ca1515c284d7ab449c6ac48ff466c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T15:28:18Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-185ca1515c284d7ab449c6ac48ff466c2023-11-20T17:51:25ZengMDPI AGNutrients2072-66432020-10-011210320710.3390/nu12103207Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate InflammationKerstin Dürholz0Jörg Hofmann1Aida Iljazovic2Julian Häger3Sébastien Lucas4Kerstin Sarter5Till Strowig6Holger Bang7Jürgen Rech8Georg Schett9Mario M. Zaiss10Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Biology, Division of Biochemistry, Friedrich-Alexander University (FAU), 91058 Erlangen, GermanyHelmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyHelmholtz Centre for Infection Research, 38124 Braunschweig, GermanyMelio.Care GmbH, 91080 Marloffstein, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, GermanyChronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls (<i>n</i> = 10) and RA patients (<i>n</i> = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro- and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies.https://www.mdpi.com/2072-6643/12/10/3207high-fiber diet (HFD)microbial metabolitesshort chain fatty acids (SCFA) |
| spellingShingle | Kerstin Dürholz Jörg Hofmann Aida Iljazovic Julian Häger Sébastien Lucas Kerstin Sarter Till Strowig Holger Bang Jürgen Rech Georg Schett Mario M. Zaiss Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation Nutrients high-fiber diet (HFD) microbial metabolites short chain fatty acids (SCFA) |
| title | Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation |
| title_full | Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation |
| title_fullStr | Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation |
| title_full_unstemmed | Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation |
| title_short | Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation |
| title_sort | dietary short term fiber interventions in arthritis patients increase systemic scfa levels and regulate inflammation |
| topic | high-fiber diet (HFD) microbial metabolites short chain fatty acids (SCFA) |
| url | https://www.mdpi.com/2072-6643/12/10/3207 |
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