Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China
Background Digit ratio, especially 2D:4D, is hypothesised as a potential biological marker of exposure to intrauterine sex hormones. The aim of this study was to investigate the association between 10 SNPs of sex steroid hormone receptor (SSHR) related genes and 2D:4D. Subjects and methods 814 colle...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2023.2225873 |
| _version_ | 1797640918427238400 |
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| author | Jie Dang Chengfeng Ma Fan Li Jing Zhang Yuan Wang Liang Peng Zhenghao Huo Hong Lu Zhanbing Ma |
| author_facet | Jie Dang Chengfeng Ma Fan Li Jing Zhang Yuan Wang Liang Peng Zhenghao Huo Hong Lu Zhanbing Ma |
| author_sort | Jie Dang |
| collection | DOAJ |
| description | Background Digit ratio, especially 2D:4D, is hypothesised as a potential biological marker of exposure to intrauterine sex hormones. The aim of this study was to investigate the association between 10 SNPs of sex steroid hormone receptor (SSHR) related genes and 2D:4D. Subjects and methods 814 college students were randomly selected as research participants. After taking pictures of both hands of the participants, Image Pro Plus (IPP) software was used to measure 2D:4D. ESR1 (rs2228480 and rs3798758), ESR2 (rs944459, rs8006145, rs928554, and rs8018687), GPER1 (rs10269151 and rs12702047), and PGR (rs1042839 and rs500760) were genotyped using multiplex PCR. Results Females had significantly higher 2D:4D in both hands than male students (p < 0.05), and the R2D:4D of the Han population was significantly higher than that of the Hui population (p < 0.05). The number of females carrying the GPER1 G allele of rs12702047 was significantly higher than that of males (p < 0.05). The L2D:4D in males was significantly different in rs1042839, and the R2D:4D in the Han ethnicity was significantly different in rs3798758. Logistic regression analysis showed that rs12702047 was significantly associated with 2D:4D in both hands (p < 0.05). Conclusions GPER1 rs12702047 may be involved in the formation of digit ratio by affecting phalanx development in the Chinese population. |
| first_indexed | 2024-03-11T13:38:04Z |
| format | Article |
| id | doaj.art-185cc898bd044b348fd8929198052f70 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-11T13:38:04Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-185cc898bd044b348fd8929198052f702023-11-02T14:32:42ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332023-01-0150130832310.1080/03014460.2023.22258732225873Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern ChinaJie Dang0Chengfeng Ma1Fan Li2Jing Zhang3Yuan Wang4Liang Peng5Zhenghao Huo6Hong Lu7Zhanbing Ma8School of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversitySchool of Basic Medicine, Ningxia Medical UniversityBackground Digit ratio, especially 2D:4D, is hypothesised as a potential biological marker of exposure to intrauterine sex hormones. The aim of this study was to investigate the association between 10 SNPs of sex steroid hormone receptor (SSHR) related genes and 2D:4D. Subjects and methods 814 college students were randomly selected as research participants. After taking pictures of both hands of the participants, Image Pro Plus (IPP) software was used to measure 2D:4D. ESR1 (rs2228480 and rs3798758), ESR2 (rs944459, rs8006145, rs928554, and rs8018687), GPER1 (rs10269151 and rs12702047), and PGR (rs1042839 and rs500760) were genotyped using multiplex PCR. Results Females had significantly higher 2D:4D in both hands than male students (p < 0.05), and the R2D:4D of the Han population was significantly higher than that of the Hui population (p < 0.05). The number of females carrying the GPER1 G allele of rs12702047 was significantly higher than that of males (p < 0.05). The L2D:4D in males was significantly different in rs1042839, and the R2D:4D in the Han ethnicity was significantly different in rs3798758. Logistic regression analysis showed that rs12702047 was significantly associated with 2D:4D in both hands (p < 0.05). Conclusions GPER1 rs12702047 may be involved in the formation of digit ratio by affecting phalanx development in the Chinese population.http://dx.doi.org/10.1080/03014460.2023.2225873sex steroid hormone receptordigit ratiosnpfoetal development |
| spellingShingle | Jie Dang Chengfeng Ma Fan Li Jing Zhang Yuan Wang Liang Peng Zhenghao Huo Hong Lu Zhanbing Ma Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China Annals of Human Biology sex steroid hormone receptor digit ratio snp foetal development |
| title | Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China |
| title_full | Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China |
| title_fullStr | Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China |
| title_full_unstemmed | Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China |
| title_short | Relationship of digit ratio with sexual steroid hormone receptor related genes - single nucleotide polymorphisms in a sample from Northern China |
| title_sort | relationship of digit ratio with sexual steroid hormone receptor related genes single nucleotide polymorphisms in a sample from northern china |
| topic | sex steroid hormone receptor digit ratio snp foetal development |
| url | http://dx.doi.org/10.1080/03014460.2023.2225873 |
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