Characterization of pancreatic cancer with ultra-low tumor mutational burden

Abstract In pancreatic cancer (PC), Tumor mutation burden (TMB) has been reported to be lower than in other cancers, with its clinical significance remaining unclear. We analyzed the dataset of whole-exome sequencing and gene expression profiling of 93 resected PC cases. The median TMB was 0.24. The...

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Автори: Taisuke Imamura, Ryo Ashida, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Keiichi Hatakeyama, Takeshi Nagashima, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi
Формат: Стаття
Мова:English
Опубліковано: Nature Portfolio 2023-03-01
Серія:Scientific Reports
Онлайн доступ:https://doi.org/10.1038/s41598-023-31579-8