Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer
PURPOSEWe aimed to evaluate whether bronchial artery can supply a percutaneously inoculated canine transmissible venereal tumor (CTVT) in a lung tumor model.METHODSFresh CTVT tissue blocks were percutaneously inoculated into unilateral or bilateral lungs of six immunosuppressed dogs at the mid zone...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-07-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/establishment-of-a-large-animal-model-for-research/54199
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| _version_ | 1797691336071053312 |
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| author | Zhichao Sun Xiao An Hongchao Liu Weihua Dong Xiangsheng Xiao |
| author_facet | Zhichao Sun Xiao An Hongchao Liu Weihua Dong Xiangsheng Xiao |
| author_sort | Zhichao Sun |
| collection | DOAJ |
| description | PURPOSEWe aimed to evaluate whether bronchial artery can supply a percutaneously inoculated canine transmissible venereal tumor (CTVT) in a lung tumor model.METHODSFresh CTVT tissue blocks were percutaneously inoculated into unilateral or bilateral lungs of six immunosuppressed dogs at the mid zone of the middle or lower lobe. Tumor growth was monitored by computed tomography (CT). Ten weeks after inoculation, pulmonary arterial digital subtraction angiography (DSA), bronchial arterial DSA, transpulmonary arterial contrast-enhanced multislice CT, transbronchial arterial contrast-enhanced multislice CT (BA-MSCT), and transpulmonary arterial lipiodol multislice CT were performed.RESULTSTumor growth was seen in all 10 inoculated sites, with a maximum diameter of 2.734±0.138 cm at 10th week. Bronchial arterial blood supply was evident in 9 nodules on DSA, and was equivocal in one which was later demonstrated on BA-MSCT. No obvious pulmonary arterial blood supply was observed in any of the nodules. Lipiodol deposition was displayed in two of the small distant metastases, which indicated that pulmonary artery was involved in the supply of the metastases.CONCLUSIONOur results demonstrated bronchial arterial blood supply in this new lung cancer model. This model may be used in further research on transbronchial arterial intervention for lung cancer. |
| first_indexed | 2024-03-12T02:11:53Z |
| format | Article |
| id | doaj.art-185e6409c12a4d98b3bfd3707e44b528 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:11:53Z |
| publishDate | 2021-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-185e6409c12a4d98b3bfd3707e44b5282023-09-06T12:19:28ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122021-07-0127447648110.5152/dir.2021.2033213049054Establishment of a large animal model for research on transbronchial arterial intervention for lung cancerZhichao Sun0Xiao An1Hongchao Liu2Weihua Dong3Xiangsheng Xiao4 Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China Department of Neoplasms and Interventional Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Interventional Radiology, Changzheng Hospital, the Second Military Medical University, Shanghai, China Department of Interventional Radiology, Changzheng Hospital, the Second Military Medical University, Shanghai, China Department of Interventional Radiology, Changzheng Hospital, the Second Military Medical University, Shanghai, China PURPOSEWe aimed to evaluate whether bronchial artery can supply a percutaneously inoculated canine transmissible venereal tumor (CTVT) in a lung tumor model.METHODSFresh CTVT tissue blocks were percutaneously inoculated into unilateral or bilateral lungs of six immunosuppressed dogs at the mid zone of the middle or lower lobe. Tumor growth was monitored by computed tomography (CT). Ten weeks after inoculation, pulmonary arterial digital subtraction angiography (DSA), bronchial arterial DSA, transpulmonary arterial contrast-enhanced multislice CT, transbronchial arterial contrast-enhanced multislice CT (BA-MSCT), and transpulmonary arterial lipiodol multislice CT were performed.RESULTSTumor growth was seen in all 10 inoculated sites, with a maximum diameter of 2.734±0.138 cm at 10th week. Bronchial arterial blood supply was evident in 9 nodules on DSA, and was equivocal in one which was later demonstrated on BA-MSCT. No obvious pulmonary arterial blood supply was observed in any of the nodules. Lipiodol deposition was displayed in two of the small distant metastases, which indicated that pulmonary artery was involved in the supply of the metastases.CONCLUSIONOur results demonstrated bronchial arterial blood supply in this new lung cancer model. This model may be used in further research on transbronchial arterial intervention for lung cancer. http://www.dirjournal.org/archives/archive-detail/article-preview/establishment-of-a-large-animal-model-for-research/54199 |
| spellingShingle | Zhichao Sun Xiao An Hongchao Liu Weihua Dong Xiangsheng Xiao Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer Diagnostic and Interventional Radiology |
| title | Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| title_full | Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| title_fullStr | Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| title_full_unstemmed | Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| title_short | Establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| title_sort | establishment of a large animal model for research on transbronchial arterial intervention for lung cancer |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/establishment-of-a-large-animal-model-for-research/54199
|
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