Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.

The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple acti...

Full description

Bibliographic Details
Main Authors:	Dahai Yu, Lin Lv, Li Fang, Bo Zhang, Junnan Wang, Ge Zhan, Lei Zhao, Xin Zhao, Baoxin Li
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2017-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5538702?pdf=render

Similar Items

Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T
by: CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun
Published: (2021-10-01)

Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells.
by: Xi Chu, et al.
Published: (2015-01-01)

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
by: Yi, Fan Teah, et al.
Published: (2017)

Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
by: Yi Fan Teah, et al.
Published: (2017-10-01)

Hydroxychloroquine induces long QT syndrome by blocking hERG channel
by: Zhao Xin, et al.
Published: (2023-05-01)

PIKfyve Sensitivity of hERG Channels
by: Tatsiana Pakladok, et al.
Published: (2013-05-01)

Berberine Induces hERG Channel Deficiency through Trafficking Inhibition
by: Kaiping Zhang, et al.
Published: (2014-08-01)

Validation of a [3H]Astemizole Binding Assay in HEK293 Cells Expressing HERG K+ Channels
by: Peter J.S. Chiu, et al.
Published: (2004-01-01)

The effect of isoliquiritigenin on the hERG potassium channel
by: Mujahid, M, et al.
Published: (2020)

Stereoselective inhibition of the hERG1 potassium channel
by: Liliana eSintra Grilo, et al.
Published: (2010-11-01)

Ion conduction through the hERG potassium channel.
by: Luisa Ceccarini, et al.
Published: (2012-01-01)

Lipid regulation of hERG1 channel function
by: Williams E. Miranda, et al.
Published: (2021-03-01)

Voltage-dependent gating of hERG potassium channels
by: Yen May eCheng, et al.
Published: (2012-05-01)

Long-chain acylcarnitines regulate the hERG channel.
by: Fabio Ferro, et al.
Published: (2012-01-01)

An Update on the Structure of hERG
by: Andrew Butler, et al.
Published: (2020-01-01)

Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency [Corrigendum]
by: Yan M, et al.
Published: (2016-11-01)

Aggregation-Induced Emission: Lighting Up hERG Potassium Channel
by: Xiaomeng Zhang, et al.
Published: (2019-02-01)

Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
by: Kaichiro Kamiya, et al.
Published: (2008-01-01)

The molecular determinants of R-roscovitine block of hERG channels.
by: Bryan Cernuda, et al.
Published: (2019-01-01)

Up-regulation of hERG K⁺ channels by B-RAF.
by: Tatsiana Pakladok, et al.
Published: (2014-01-01)

Rapid characterisation of hERG channel kinetics II: temperature dependence
by: Lei, CL, et al.
Published: (2019)

High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition
by: Yuan-Qi Shi, et al.
Published: (2015-08-01)

Ginkgo biloba Extract and Ginkgolide Antiarrhythmic Potential by Targeting hERG and ICa-L Channel
by: Xin Zhao, et al.
Published: (2013-01-01)

New Insights into Ion Channels: Predicting hERG-Drug Interactions
by: Michael Fitzpatrick Wempe
Published: (2022-09-01)

Structural modeling of hERG channel–drug interactions using Rosetta
by: Aiyana M. Emigh Cortez, et al.
Published: (2023-11-01)

Noncanonical electromechanical coupling paths in cardiac hERG potassium channel
by: Carlos A. Z. Bassetto, et al.
Published: (2023-02-01)

Structural modeling of the hERG potassium channel and associated drug interactions
by: Jan Maly, et al.
Published: (2022-09-01)

hERG K+ Channels Promote Survival of Irradiated Leukemia Cells
by: Daniela Palme, et al.
Published: (2020-04-01)

A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel
by: Shoko Kakusaka, et al.
Published: (2009-01-01)

Hysteretic hERG channel gating current recorded at physiological temperature
by: David K. Jones
Published: (2022-04-01)

Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation
by: Yu Patrick Shi, et al.
Published: (2020-02-01)

Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes
by: Janire Urrutia, et al.
Published: (2016-12-01)

An Insight into the Potassium Currents of hERG and Their Simulation
by: Rolando Guidelli
Published: (2023-04-01)

Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols
by: Beattie, K, et al.
Published: (2017)

Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel
by: Ng, Hui Qi, et al.
Published: (2013)

Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.
by: Ying Wang, et al.
Published: (2012-01-01)

The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models
by: Ginevra Chioccioli Altadonna, et al.
Published: (2022-11-01)

Rapid characterisation of hERG channel kinetics I: using an automated high-throughput system
by: Lei, CL, et al.
Published: (2019)

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue
by: Matthew V. Helliwell, et al.
Published: (2023-08-01)

Prognostic role of hERG1 Potassium Channels in Neuroendocrine Tumours of the Ileum and Pancreas
by: Jessica Iorio, et al.
Published: (2022-09-01)