Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease

Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: Implications for Alzheimer's disease

Cerebral blood flow is mainly regulated by nitrergic (parasympathetic, postganglionic) nerves and nitric oxide (NO) liberated from endothelial cells in response to shear stress and stretch of vasculature, whereas sympathetic vasoconstrictor control is quite weak. On the other hand, peripheral vascul...

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Bibliographic Details
Main Authors:	Noboru Toda, Tomio Okamura
Format:	Article
Language:	English
Published:	Elsevier 2016-08-01
Series:	Journal of Pharmacological Sciences
Subjects:	Alzheimer's disease Cerebral blood flow regulation Cigarette smoking Nitric oxide Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861316300834

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