Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension
Pulmonary hypertension is a rare condition that impairs patients’ quality of life and life expectancy. The development of noninvasive instruments may help elucidate the prognosis of this cardiorespiratory disease. We aimed to evaluate the utility of routinely performed noninvasive test results as pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/7/1297 |
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| author | Mario E. Baltazares-Lipp Alberto Aguilera-Velasco Arnoldo Aquino-Gálvez Rafael Velázquez-Cruz Rafael J. Hernández-Zenteno Noé Alvarado-Vásquez Angel Camarena M. Patricia Sierra-Vargas Juan L. Chávez-Pacheco Víctor Ruiz Citlaltepetl Salinas-Lara Martha L. Tena-Suck Yair Romero Luz M. Torres-Espíndola Manuel Castillejos-López |
| author_facet | Mario E. Baltazares-Lipp Alberto Aguilera-Velasco Arnoldo Aquino-Gálvez Rafael Velázquez-Cruz Rafael J. Hernández-Zenteno Noé Alvarado-Vásquez Angel Camarena M. Patricia Sierra-Vargas Juan L. Chávez-Pacheco Víctor Ruiz Citlaltepetl Salinas-Lara Martha L. Tena-Suck Yair Romero Luz M. Torres-Espíndola Manuel Castillejos-López |
| author_sort | Mario E. Baltazares-Lipp |
| collection | DOAJ |
| description | Pulmonary hypertension is a rare condition that impairs patients’ quality of life and life expectancy. The development of noninvasive instruments may help elucidate the prognosis of this cardiorespiratory disease. We aimed to evaluate the utility of routinely performed noninvasive test results as prognostic markers in patients with pulmonary hypertension. We enrolled 198 patients with mean pulmonary artery pressure >25 mmHg measured at cardiac catheterisation or echocardiographic pulmonary artery systolic pressure > 40 mmHg and tricuspid regurgitation Vmax >2.9 m/s, and clinical information regarding management and follow-up studies from the date of diagnosis. Multivariate analysis revealed that female sex [HR: 0.21, (95% CI: 0.07–0.64); <i>p</i> = 0.006], the presence of collagenopathies [HR: 8.63, (95% CI: 2.38–31.32); <i>p</i> = 0.001], an increased red blood cell distribution width [HR: 1.25, (95% CI: 1.04–1.49); <i>p</i> = 0.017] and an increased electrocardiographic P axis (P°)/T axis (T°) ratio [HR: 0.93, (95% CI: 0.88–0.98); <i>p</i> = 0.009] were severity-associated factors, while older age [HR: 1.57, (95% CI: 1.04–1.28); <i>p</i> = 0.006], an increased QRS axis (QRS°)/T° ratio [HR: 1.21, (95% CI: 1.09–1.34); <i>p</i> < 0.001], forced expiratory volume in 1 s [HR: 0.94, (95% CI: 0.91–0.98); <i>p</i> = 0.01] and haematocrit [HR: 0.93, (95% CI: 0.87–0.99); <i>p</i> = 0.04] were mortality-associated factors. Our results support the importance of red blood cell distribution width, electrocardiographic ratios and collagenopathies for assessing pulmonary hypertension prognosis. |
| first_indexed | 2024-03-10T09:41:48Z |
| format | Article |
| id | doaj.art-1862673b5cb342ceb193f378bc2c323a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T09:41:48Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-1862673b5cb342ceb193f378bc2c323a2023-11-22T03:35:48ZengMDPI AGDiagnostics2075-44182021-07-01117129710.3390/diagnostics11071297Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary HypertensionMario E. Baltazares-Lipp0Alberto Aguilera-Velasco1Arnoldo Aquino-Gálvez2Rafael Velázquez-Cruz3Rafael J. Hernández-Zenteno4Noé Alvarado-Vásquez5Angel Camarena6M. Patricia Sierra-Vargas7Juan L. Chávez-Pacheco8Víctor Ruiz9Citlaltepetl Salinas-Lara10Martha L. Tena-Suck11Yair Romero12Luz M. Torres-Espíndola13Manuel Castillejos-López14Department of Hemodynamics and Echocardiography, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoEpidemiology and Statistics Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoLaboratory of Molecular Biology, Pulmonary Fibrosis Research Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoGenomics of Bone Metabolism Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, MexicoClinical Service of Chronic Obstructive Pulmonary Disease, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoBiochemistry Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoLaboratory of HLA, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoToxicology and Environmental Medicine Research Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoLaboratory of Pharmacology, National Institute of Paediatrics, Mexico City 04530, MexicoLaboratory of Molecular Biology, Pulmonary Fibrosis Research Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoLaboratory of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City 14269, MexicoLaboratory of Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City 14269, MexicoFaculty of Sciences, National Autonomous University of Mexico, Mexico City 04510, MexicoLaboratory of Pharmacology, National Institute of Paediatrics, Mexico City 04530, MexicoEpidemiology and Statistics Department, National Institute of Respiratory Diseases Ismael Cosio Villegas, Mexico City 14080, MexicoPulmonary hypertension is a rare condition that impairs patients’ quality of life and life expectancy. The development of noninvasive instruments may help elucidate the prognosis of this cardiorespiratory disease. We aimed to evaluate the utility of routinely performed noninvasive test results as prognostic markers in patients with pulmonary hypertension. We enrolled 198 patients with mean pulmonary artery pressure >25 mmHg measured at cardiac catheterisation or echocardiographic pulmonary artery systolic pressure > 40 mmHg and tricuspid regurgitation Vmax >2.9 m/s, and clinical information regarding management and follow-up studies from the date of diagnosis. Multivariate analysis revealed that female sex [HR: 0.21, (95% CI: 0.07–0.64); <i>p</i> = 0.006], the presence of collagenopathies [HR: 8.63, (95% CI: 2.38–31.32); <i>p</i> = 0.001], an increased red blood cell distribution width [HR: 1.25, (95% CI: 1.04–1.49); <i>p</i> = 0.017] and an increased electrocardiographic P axis (P°)/T axis (T°) ratio [HR: 0.93, (95% CI: 0.88–0.98); <i>p</i> = 0.009] were severity-associated factors, while older age [HR: 1.57, (95% CI: 1.04–1.28); <i>p</i> = 0.006], an increased QRS axis (QRS°)/T° ratio [HR: 1.21, (95% CI: 1.09–1.34); <i>p</i> < 0.001], forced expiratory volume in 1 s [HR: 0.94, (95% CI: 0.91–0.98); <i>p</i> = 0.01] and haematocrit [HR: 0.93, (95% CI: 0.87–0.99); <i>p</i> = 0.04] were mortality-associated factors. Our results support the importance of red blood cell distribution width, electrocardiographic ratios and collagenopathies for assessing pulmonary hypertension prognosis.https://www.mdpi.com/2075-4418/11/7/1297red blood cell distribution widthsecondary pulmonary hypertensionseverityprognosismortality |
| spellingShingle | Mario E. Baltazares-Lipp Alberto Aguilera-Velasco Arnoldo Aquino-Gálvez Rafael Velázquez-Cruz Rafael J. Hernández-Zenteno Noé Alvarado-Vásquez Angel Camarena M. Patricia Sierra-Vargas Juan L. Chávez-Pacheco Víctor Ruiz Citlaltepetl Salinas-Lara Martha L. Tena-Suck Yair Romero Luz M. Torres-Espíndola Manuel Castillejos-López Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension Diagnostics red blood cell distribution width secondary pulmonary hypertension severity prognosis mortality |
| title | Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension |
| title_full | Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension |
| title_fullStr | Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension |
| title_full_unstemmed | Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension |
| title_short | Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension |
| title_sort | evaluating of red blood cell distribution width comorbidities and electrocardiographic ratios as predictors of prognosis in patients with pulmonary hypertension |
| topic | red blood cell distribution width secondary pulmonary hypertension severity prognosis mortality |
| url | https://www.mdpi.com/2075-4418/11/7/1297 |
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