Comparison between obese and non-obese nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions that are characterized by excess accumulation of fat in the liver, and is diagnosed after exclusion of significant alcohol intake and other causes of chronic liver disease. In the majority of cases, NAFLD is associat...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2023-02-01
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| Series: | Clinical and Molecular Hepatology |
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| Online Access: | http://e-cmh.org/upload/pdf/cmh-2022-0350.pdf |
| _version_ | 1797871486783979520 |
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| author | Wah-Kheong Chan |
| author_facet | Wah-Kheong Chan |
| author_sort | Wah-Kheong Chan |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions that are characterized by excess accumulation of fat in the liver, and is diagnosed after exclusion of significant alcohol intake and other causes of chronic liver disease. In the majority of cases, NAFLD is associated with overnutrition and obesity, although it may be also found in lean or non-obese individuals. It has been estimated that 19.2% of NAFLD patients are lean and 40.8% are non-obese. The proportion of patients with more severe liver disease and the incidence of all-cause mortality, liver-related mortality, and cardiovascular mortality among non-obese and obese NAFLD patients varies across studies and may be confounded by selection bias, underestimation of alcohol intake, and unaccounted weight changes over time. Genetic factors may have a greater effect towards the development of NAFLD in lean or non-obese individuals, but the effect may be less pronounced in the presence of strong environmental factors, such as poor dietary choices and a sedentary lifestyle, as body mass index increases in the obese state. Overall, non-invasive tests, such as the Fibrosis-4 index, NAFLD fibrosis score, and liver stiffness measurement, perform better in lean or non-obese patients compared to obese patients. Lifestyle intervention works in non-obese patients, and less amount of weight loss may be required to achieve similar results compared to obese patients. Pharmacological therapy in non-obese NAFLD patients may require special consideration and a different approach compared to obese patients. |
| first_indexed | 2024-04-10T00:44:41Z |
| format | Article |
| id | doaj.art-186279c3758a4d9e8e284128920de9d6 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-10T00:44:41Z |
| publishDate | 2023-02-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-186279c3758a4d9e8e284128920de9d62023-03-14T01:46:51ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2023-02-0129SupplS58S6710.3350/cmh.2022.03501739Comparison between obese and non-obese nonalcoholic fatty liver diseaseWah-Kheong ChanNonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions that are characterized by excess accumulation of fat in the liver, and is diagnosed after exclusion of significant alcohol intake and other causes of chronic liver disease. In the majority of cases, NAFLD is associated with overnutrition and obesity, although it may be also found in lean or non-obese individuals. It has been estimated that 19.2% of NAFLD patients are lean and 40.8% are non-obese. The proportion of patients with more severe liver disease and the incidence of all-cause mortality, liver-related mortality, and cardiovascular mortality among non-obese and obese NAFLD patients varies across studies and may be confounded by selection bias, underestimation of alcohol intake, and unaccounted weight changes over time. Genetic factors may have a greater effect towards the development of NAFLD in lean or non-obese individuals, but the effect may be less pronounced in the presence of strong environmental factors, such as poor dietary choices and a sedentary lifestyle, as body mass index increases in the obese state. Overall, non-invasive tests, such as the Fibrosis-4 index, NAFLD fibrosis score, and liver stiffness measurement, perform better in lean or non-obese patients compared to obese patients. Lifestyle intervention works in non-obese patients, and less amount of weight loss may be required to achieve similar results compared to obese patients. Pharmacological therapy in non-obese NAFLD patients may require special consideration and a different approach compared to obese patients.http://e-cmh.org/upload/pdf/cmh-2022-0350.pdfnonalcoholic fatty liver diseasenon-obeselean |
| spellingShingle | Wah-Kheong Chan Comparison between obese and non-obese nonalcoholic fatty liver disease Clinical and Molecular Hepatology nonalcoholic fatty liver disease non-obese lean |
| title | Comparison between obese and non-obese nonalcoholic fatty liver disease |
| title_full | Comparison between obese and non-obese nonalcoholic fatty liver disease |
| title_fullStr | Comparison between obese and non-obese nonalcoholic fatty liver disease |
| title_full_unstemmed | Comparison between obese and non-obese nonalcoholic fatty liver disease |
| title_short | Comparison between obese and non-obese nonalcoholic fatty liver disease |
| title_sort | comparison between obese and non obese nonalcoholic fatty liver disease |
| topic | nonalcoholic fatty liver disease non-obese lean |
| url | http://e-cmh.org/upload/pdf/cmh-2022-0350.pdf |
| work_keys_str_mv | AT wahkheongchan comparisonbetweenobeseandnonobesenonalcoholicfattyliverdisease |