Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules
ABSTRACT Objective To evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in reducing the volume of cystic and mixed thyroid nodules. Materials and methods A total of 36 patients with nodules treated with PEI and 13 individuals who declined PEI and were followed clinically or...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2016-02-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300211&lng=en&tlng=en |
| _version_ | 1818573383014547456 |
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| author | Mari Cassol Ferreira Camila Piaia Ana Carolina Cadore |
| author_facet | Mari Cassol Ferreira Camila Piaia Ana Carolina Cadore |
| author_sort | Mari Cassol Ferreira |
| collection | DOAJ |
| description | ABSTRACT Objective To evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in reducing the volume of cystic and mixed thyroid nodules. Materials and methods A total of 36 patients with nodules treated with PEI and 13 individuals who declined PEI and were followed clinically or received other non surgical treatment (control group). Assessments were performed at baseline (immediately before treatment in the PEI group or evaluation of the nodule on ultrasonography in the control group) at short-term (on average 30 days after the last injection in the PEI group), and long-term (on average 14 months after baseline in the PEI group or 26 months after baseline in the control group). Results In the PEI group, the mean baseline volume of 10.4 ± 9.8 cm3 reduced at short-term follow-up to 2.9 ± 3.1 cm3 (67.7 ± 19.9%, p < 0.001) and at long-term follow-up to 2.0 ± 2.5 cm3 (78.2 ± 19.5%, p < 0.01 versus baseline and p = 0.009 versus short-term follow-up). Both types of nodules showed similar degrees of reduction. In the control group, mean volume was 5.8 ± 3.4 cm3 at baseline and 6.2 ± 3.0 cm3 at long-term follow-up (p = 0.507). Compared with the control group, the PEI group showed larger reduction (p < 0.001). Conclusions PEI is effective in reducing the volume of cystic and mixed benign thyroid nodules, with sustained long-term efficacy and better outcome when compared with conservative therapies. Treatment with PEI is a safe alternative, with minimal, transient and self-limited adverse events. |
| first_indexed | 2024-12-15T00:10:26Z |
| format | Article |
| id | doaj.art-18636ad1d72b436ab41ade68be609208 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-15T00:10:26Z |
| publishDate | 2016-02-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-18636ad1d72b436ab41ade68be6092082022-12-21T22:42:36ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922016-02-0160321121610.1590/2359-3997000000120S2359-39972016000300211Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodulesMari Cassol FerreiraCamila PiaiaAna Carolina CadoreABSTRACT Objective To evaluate the efficacy and safety of percutaneous ethanol injection (PEI) in reducing the volume of cystic and mixed thyroid nodules. Materials and methods A total of 36 patients with nodules treated with PEI and 13 individuals who declined PEI and were followed clinically or received other non surgical treatment (control group). Assessments were performed at baseline (immediately before treatment in the PEI group or evaluation of the nodule on ultrasonography in the control group) at short-term (on average 30 days after the last injection in the PEI group), and long-term (on average 14 months after baseline in the PEI group or 26 months after baseline in the control group). Results In the PEI group, the mean baseline volume of 10.4 ± 9.8 cm3 reduced at short-term follow-up to 2.9 ± 3.1 cm3 (67.7 ± 19.9%, p < 0.001) and at long-term follow-up to 2.0 ± 2.5 cm3 (78.2 ± 19.5%, p < 0.01 versus baseline and p = 0.009 versus short-term follow-up). Both types of nodules showed similar degrees of reduction. In the control group, mean volume was 5.8 ± 3.4 cm3 at baseline and 6.2 ± 3.0 cm3 at long-term follow-up (p = 0.507). Compared with the control group, the PEI group showed larger reduction (p < 0.001). Conclusions PEI is effective in reducing the volume of cystic and mixed benign thyroid nodules, with sustained long-term efficacy and better outcome when compared with conservative therapies. Treatment with PEI is a safe alternative, with minimal, transient and self-limited adverse events.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300211&lng=en&tlng=enThyroid noduleetanolinterventional ultrasonographypercutaneous administrationultrasonography |
| spellingShingle | Mari Cassol Ferreira Camila Piaia Ana Carolina Cadore Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules Archives of Endocrinology and Metabolism Thyroid nodule etanol interventional ultrasonography percutaneous administration ultrasonography |
| title | Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| title_full | Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| title_fullStr | Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| title_full_unstemmed | Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| title_short | Percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| title_sort | percutaneous ethanol injection versus conservative treatment for benign cystic and mixed thyroid nodules |
| topic | Thyroid nodule etanol interventional ultrasonography percutaneous administration ultrasonography |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300211&lng=en&tlng=en |
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