Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides
Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, modification of 2-oxyl benzimidazole skeleton using maleimide compounds via C–H activation has remained unprecedented. Herei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2023-11-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922000977 |
| _version_ | 1797372907143299072 |
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| author | Wei-Yi Pu Xin-Yi Chen Lin Dong |
| author_facet | Wei-Yi Pu Xin-Yi Chen Lin Dong |
| author_sort | Wei-Yi Pu |
| collection | DOAJ |
| description | Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, modification of 2-oxyl benzimidazole skeleton using maleimide compounds via C–H activation has remained unprecedented. Herein, we developed a rhodium(III)-catalyzed [5 + 1] cascade spiroannulation to construct diversified novel benzimidazole-incorporated spirosuccinimide derivatives from 2-oxyl benzimidazoles and maleimides. |
| first_indexed | 2024-03-08T18:41:33Z |
| format | Article |
| id | doaj.art-186493019c514ab8b5784a064934df46 |
| institution | Directory Open Access Journal |
| issn | 2666-5549 |
| language | English |
| last_indexed | 2024-03-08T18:41:33Z |
| publishDate | 2023-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Green Synthesis and Catalysis |
| spelling | doaj.art-186493019c514ab8b5784a064934df462023-12-29T04:46:13ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492023-11-0144338341Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimidesWei-Yi Pu0Xin-Yi Chen1Lin Dong2Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaCorresponding author.; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, ChinaTransition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds. However, modification of 2-oxyl benzimidazole skeleton using maleimide compounds via C–H activation has remained unprecedented. Herein, we developed a rhodium(III)-catalyzed [5 + 1] cascade spiroannulation to construct diversified novel benzimidazole-incorporated spirosuccinimide derivatives from 2-oxyl benzimidazoles and maleimides.http://www.sciencedirect.com/science/article/pii/S2666554922000977Rh(III)-catalysis2-Oxyl benzimidazoleMaleimidesSpirocyclization |
| spellingShingle | Wei-Yi Pu Xin-Yi Chen Lin Dong Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides Green Synthesis and Catalysis Rh(III)-catalysis 2-Oxyl benzimidazole Maleimides Spirocyclization |
| title | Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides |
| title_full | Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides |
| title_fullStr | Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides |
| title_full_unstemmed | Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides |
| title_short | Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides |
| title_sort | rh iii catalyzed 5 1 spirocyclization to produce novel benzimidazole incorporated spirosuccinimides |
| topic | Rh(III)-catalysis 2-Oxyl benzimidazole Maleimides Spirocyclization |
| url | http://www.sciencedirect.com/science/article/pii/S2666554922000977 |
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