Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study
Background/Aims Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-09-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-111.pdf |
| _version_ | 1831787747030859776 |
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| author | Jaeyoung Cho Chang-Hoon Lee Deog Kyeom Kim Hun-Gyu Hwang Yu-Il Kim Hye Sook Choi Jeong-Woong Park Kwang Ha Yoo Ki-Suck Jung Sang-Do Lee on behalf of the KOLD and KOCOSS Investigators |
| author_facet | Jaeyoung Cho Chang-Hoon Lee Deog Kyeom Kim Hun-Gyu Hwang Yu-Il Kim Hye Sook Choi Jeong-Woong Park Kwang Ha Yoo Ki-Suck Jung Sang-Do Lee on behalf of the KOLD and KOCOSS Investigators |
| author_sort | Jaeyoung Cho |
| collection | DOAJ |
| description | Background/Aims Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ by gender. Methods We recruited patients with COPD from two Korean multicenter prospective cohorts. After propensity score matching, the main outcome, the incidence of moderate or severe exacerbations was analyzed using a negative binomial regression model. We also assessed changes in lung function and symptom scores including the St. George’s respiratory questionnaire for COPD (SGRQ-C), COPD assessment test (CAT), and the modified Medical Research Council (mMRC) dyspnea score. Results After propensity score matching, 74 women and 74 men with COPD were included. The incidence rates of exacerbations in women and men were not significantly different (incidence rate ratio, 1.49; 95% confidence interval [CI], 0.88 to 2.54). There was no significant difference in the incidence rates adjusted for medication possession ratios of long-acting muscarinic antagonists, long-acting β-agonists, and inhaled corticosteroids during the follow-up period (incidence rate ratio, 1.47; 95% CI, 0.86 to 2.52). Rates of decline in post-bronchodilator forced expiratory volume in 1 second and forced vital capacity did not differ between women and men during 48 months of follow-up. The changes in scores on the SGRQ-C, CAT, and mMRC Questionnaire in women were also similar to those in men. Conclusions We observed no gender differences in the rate of exacerbations of COPD in a prospective longitudinal study. Further studies are needed to confirm these findings in the general COPD population. |
| first_indexed | 2024-12-22T13:37:04Z |
| format | Article |
| id | doaj.art-1864e35a860647acaf1070231255f3be |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T13:37:04Z |
| publishDate | 2020-09-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-1864e35a860647acaf1070231255f3be2022-12-21T18:24:02ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-09-013551154116310.3904/kjim.2019.111170318Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort studyJaeyoung Cho0Chang-Hoon Lee1Deog Kyeom Kim2Hun-Gyu Hwang3Yu-Il Kim4Hye Sook Choi5Jeong-Woong Park6Kwang Ha Yoo7Ki-Suck Jung8Sang-Do Lee9on behalf of the KOLD and KOCOSS Investigators Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea Division of Respiratory, Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Gumi, Korea Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea Division of Pulmonology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims Despite increasing awareness of the burden of chronic obstructive pulmonary disease (COPD) in women, knowledge regarding gender differences in COPD outcomes is limited. Therefore, we aimed to evaluate whether COPD outcomes, including exacerbations, lung function, and symptoms differ by gender. Methods We recruited patients with COPD from two Korean multicenter prospective cohorts. After propensity score matching, the main outcome, the incidence of moderate or severe exacerbations was analyzed using a negative binomial regression model. We also assessed changes in lung function and symptom scores including the St. George’s respiratory questionnaire for COPD (SGRQ-C), COPD assessment test (CAT), and the modified Medical Research Council (mMRC) dyspnea score. Results After propensity score matching, 74 women and 74 men with COPD were included. The incidence rates of exacerbations in women and men were not significantly different (incidence rate ratio, 1.49; 95% confidence interval [CI], 0.88 to 2.54). There was no significant difference in the incidence rates adjusted for medication possession ratios of long-acting muscarinic antagonists, long-acting β-agonists, and inhaled corticosteroids during the follow-up period (incidence rate ratio, 1.47; 95% CI, 0.86 to 2.52). Rates of decline in post-bronchodilator forced expiratory volume in 1 second and forced vital capacity did not differ between women and men during 48 months of follow-up. The changes in scores on the SGRQ-C, CAT, and mMRC Questionnaire in women were also similar to those in men. Conclusions We observed no gender differences in the rate of exacerbations of COPD in a prospective longitudinal study. Further studies are needed to confirm these findings in the general COPD population.http://www.kjim.org/upload/pdf/kjim-2019-111.pdfchronic obstructive pulmonary diseasewomenmenprospective studies |
| spellingShingle | Jaeyoung Cho Chang-Hoon Lee Deog Kyeom Kim Hun-Gyu Hwang Yu-Il Kim Hye Sook Choi Jeong-Woong Park Kwang Ha Yoo Ki-Suck Jung Sang-Do Lee on behalf of the KOLD and KOCOSS Investigators Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study The Korean Journal of Internal Medicine chronic obstructive pulmonary disease women men prospective studies |
| title | Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study |
| title_full | Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study |
| title_fullStr | Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study |
| title_full_unstemmed | Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study |
| title_short | Impact of gender on chronic obstructive pulmonary disease outcomes: a propensity score-matched analysis of a prospective cohort study |
| title_sort | impact of gender on chronic obstructive pulmonary disease outcomes a propensity score matched analysis of a prospective cohort study |
| topic | chronic obstructive pulmonary disease women men prospective studies |
| url | http://www.kjim.org/upload/pdf/kjim-2019-111.pdf |
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