Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature
Abstract Background The locally advanced cervical cancer (LACC) of FIGO stage IB3-IIA2 is characterized by large local mass, poor prognosis and survival rate. Tumor response to neoadjuvant chemotherapy for LACC, utilized as a surrogate endpoint, is urgently needed to improve. Given that the antitumo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-023-01394-w |
| _version_ | 1797454061964886016 |
|---|---|
| author | Linlin Liu Xianbo Deng Shuang Guo Shouhua Yang |
| author_facet | Linlin Liu Xianbo Deng Shuang Guo Shouhua Yang |
| author_sort | Linlin Liu |
| collection | DOAJ |
| description | Abstract Background The locally advanced cervical cancer (LACC) of FIGO stage IB3-IIA2 is characterized by large local mass, poor prognosis and survival rate. Tumor response to neoadjuvant chemotherapy for LACC, utilized as a surrogate endpoint, is urgently needed to improve. Given that the antitumor immune response can be suppressed by programed death-1 axis, the treatment paradigm of neoadjuvant chemotherapy combined with immunotherapy has been explored as one of the prognostic treatments in a variety of solid carcinoma. So far, the application of sintilimab, a domestic immune checkpoint inhibitor, combined with neoadjuvant chemotherapy is still limited in LACC, especially in large lesions. Case description We present three postmenopausal women diagnosed with FIGO stage IB3-IIA2 cervical squamous cell carcinoma with lesions larger than 5 cm. Demographic, clinical, histopathological, laboratory and imaging data were record. At the completion of the neoadjuvant therapy with paclitaxel plus carboplatin combined with sintilimab, all patients underwent hysterectomy. After neoadjuvant treatment, a pathologic complete response in case 1 and partial responses in case 2 and case 3 were achieved, and neither patient showed any relapse during the follow-up period of 16 to 22 months. Conclusions This report provide evidence to support the combination of sintilimab with neoadjuvant chemotherapy in cervical cancer, which has yet to be validated in prospective studies. More clinical data are needed to verify the effectiveness of the combined regimens. This literature review also collected studies involving potential predictors of response to NACT and immunotherapy, which would be helpful in stratifying patients for future trials. |
| first_indexed | 2024-03-09T15:31:50Z |
| format | Article |
| id | doaj.art-1865c1dc0b4a41a188fc9f5ef61e3d7f |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-03-09T15:31:50Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-1865c1dc0b4a41a188fc9f5ef61e3d7f2023-11-26T12:11:01ZengBMCDiagnostic Pathology1746-15962023-09-0118111110.1186/s13000-023-01394-wSuccessful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literatureLinlin Liu0Xianbo Deng1Shuang Guo2Shouhua Yang3Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background The locally advanced cervical cancer (LACC) of FIGO stage IB3-IIA2 is characterized by large local mass, poor prognosis and survival rate. Tumor response to neoadjuvant chemotherapy for LACC, utilized as a surrogate endpoint, is urgently needed to improve. Given that the antitumor immune response can be suppressed by programed death-1 axis, the treatment paradigm of neoadjuvant chemotherapy combined with immunotherapy has been explored as one of the prognostic treatments in a variety of solid carcinoma. So far, the application of sintilimab, a domestic immune checkpoint inhibitor, combined with neoadjuvant chemotherapy is still limited in LACC, especially in large lesions. Case description We present three postmenopausal women diagnosed with FIGO stage IB3-IIA2 cervical squamous cell carcinoma with lesions larger than 5 cm. Demographic, clinical, histopathological, laboratory and imaging data were record. At the completion of the neoadjuvant therapy with paclitaxel plus carboplatin combined with sintilimab, all patients underwent hysterectomy. After neoadjuvant treatment, a pathologic complete response in case 1 and partial responses in case 2 and case 3 were achieved, and neither patient showed any relapse during the follow-up period of 16 to 22 months. Conclusions This report provide evidence to support the combination of sintilimab with neoadjuvant chemotherapy in cervical cancer, which has yet to be validated in prospective studies. More clinical data are needed to verify the effectiveness of the combined regimens. This literature review also collected studies involving potential predictors of response to NACT and immunotherapy, which would be helpful in stratifying patients for future trials.https://doi.org/10.1186/s13000-023-01394-wLocally advanced cervical cancerNeoadjuvant chemotherapySintilimabImmune checkpoint inhibitorCase series |
| spellingShingle | Linlin Liu Xianbo Deng Shuang Guo Shouhua Yang Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature Diagnostic Pathology Locally advanced cervical cancer Neoadjuvant chemotherapy Sintilimab Immune checkpoint inhibitor Case series |
| title | Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature |
| title_full | Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature |
| title_fullStr | Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature |
| title_full_unstemmed | Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature |
| title_short | Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature |
| title_sort | successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer case series and review of the literature |
| topic | Locally advanced cervical cancer Neoadjuvant chemotherapy Sintilimab Immune checkpoint inhibitor Case series |
| url | https://doi.org/10.1186/s13000-023-01394-w |
| work_keys_str_mv | AT linlinliu successfulneoadjuvantchemotherapyplussintilimabforlocallyadvancedcervicalcancercaseseriesandreviewoftheliterature AT xianbodeng successfulneoadjuvantchemotherapyplussintilimabforlocallyadvancedcervicalcancercaseseriesandreviewoftheliterature AT shuangguo successfulneoadjuvantchemotherapyplussintilimabforlocallyadvancedcervicalcancercaseseriesandreviewoftheliterature AT shouhuayang successfulneoadjuvantchemotherapyplussintilimabforlocallyadvancedcervicalcancercaseseriesandreviewoftheliterature |