A Chronically Implantable Bidirectional Neural Interface for Non-human Primates
Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. W...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-09-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00514/full |
| _version_ | 1828930366543495168 |
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| author | Misako Komatsu Eriko Sugano Hiroshi Tomita Naotaka Fujii |
| author_facet | Misako Komatsu Eriko Sugano Hiroshi Tomita Naotaka Fujii |
| author_sort | Misako Komatsu |
| collection | DOAJ |
| description | Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. We aimed to develop a chronically implantable device for photostimulation of the brain of non-human primates. We used a micro-light-emitting diode (LED) array with a flexible polyimide film. The array was combined with a whole-cortex electrocorticographic (ECoG) electrode array for simultaneous photostimulation and recording. Channelrhodopsin-2 (ChR2) was virally transduced into the cerebral cortex of common marmosets, and then the device was epidurally implanted into their brains. We recorded the neural activity during photostimulation of the awake monkeys for 4 months. The neural responses gradually increased after the virus injection for ~8 weeks and remained constant for another 8 weeks. The micro-LED and ECoG arrays allowed semi-invasive simultaneous stimulation and recording during long-term implantation in the brains of non-human primates. The development of this device represents substantial progress in the field of optogenetic applications. |
| first_indexed | 2024-12-14T00:31:50Z |
| format | Article |
| id | doaj.art-18669e2efefc4b65ba8d74a7f4254b51 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-14T00:31:50Z |
| publishDate | 2017-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-18669e2efefc4b65ba8d74a7f4254b512022-12-21T23:24:49ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-09-011110.3389/fnins.2017.00514254701A Chronically Implantable Bidirectional Neural Interface for Non-human PrimatesMisako Komatsu0Eriko Sugano1Hiroshi Tomita2Naotaka Fujii3Ichinohe Group, Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Brain Science InstituteSaitama, JapanDepartment of Chemistry and Biological Sciences, Iwate UniversityIwate, JapanDepartment of Chemistry and Biological Sciences, Iwate UniversityIwate, JapanLaboratory for Adaptive Intelligence, RIKEN Brain Science InstituteSaitama, JapanOptogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. We aimed to develop a chronically implantable device for photostimulation of the brain of non-human primates. We used a micro-light-emitting diode (LED) array with a flexible polyimide film. The array was combined with a whole-cortex electrocorticographic (ECoG) electrode array for simultaneous photostimulation and recording. Channelrhodopsin-2 (ChR2) was virally transduced into the cerebral cortex of common marmosets, and then the device was epidurally implanted into their brains. We recorded the neural activity during photostimulation of the awake monkeys for 4 months. The neural responses gradually increased after the virus injection for ~8 weeks and remained constant for another 8 weeks. The micro-LED and ECoG arrays allowed semi-invasive simultaneous stimulation and recording during long-term implantation in the brains of non-human primates. The development of this device represents substantial progress in the field of optogenetic applications.http://journal.frontiersin.org/article/10.3389/fnins.2017.00514/fullelectrocorticography (ECoG)common marmosetmonkeyoptogeneticsbrain–machine interface (BMI) |
| spellingShingle | Misako Komatsu Eriko Sugano Hiroshi Tomita Naotaka Fujii A Chronically Implantable Bidirectional Neural Interface for Non-human Primates Frontiers in Neuroscience electrocorticography (ECoG) common marmoset monkey optogenetics brain–machine interface (BMI) |
| title | A Chronically Implantable Bidirectional Neural Interface for Non-human Primates |
| title_full | A Chronically Implantable Bidirectional Neural Interface for Non-human Primates |
| title_fullStr | A Chronically Implantable Bidirectional Neural Interface for Non-human Primates |
| title_full_unstemmed | A Chronically Implantable Bidirectional Neural Interface for Non-human Primates |
| title_short | A Chronically Implantable Bidirectional Neural Interface for Non-human Primates |
| title_sort | chronically implantable bidirectional neural interface for non human primates |
| topic | electrocorticography (ECoG) common marmoset monkey optogenetics brain–machine interface (BMI) |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00514/full |
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