Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes
Objective To develop an experimental porcine model of tricuspid regurgitation using two induction routes: the inferior vena cava and superior vena cava. Methods Tricuspid regurgitation was generated using the loop wire cutting method. The tricuspid regurgitation jet direction was controlled by acces...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-03-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605241233524 |
| _version_ | 1797258421612838912 |
|---|---|
| author | Ji Soo Oh Ga Yun Kim Seok Hyun Kim Sang Hyun Lee Yong Hyun Park June Hong Kim Min Ku Chon |
| author_facet | Ji Soo Oh Ga Yun Kim Seok Hyun Kim Sang Hyun Lee Yong Hyun Park June Hong Kim Min Ku Chon |
| author_sort | Ji Soo Oh |
| collection | DOAJ |
| description | Objective To develop an experimental porcine model of tricuspid regurgitation using two induction routes: the inferior vena cava and superior vena cava. Methods Tricuspid regurgitation was generated using the loop wire cutting method. The tricuspid regurgitation jet direction was controlled by accessing the valve through the inferior (n = 7) or superior (n = 6) vena cava. The occurrence, direction, and progression of tricuspid regurgitation were assessed postoperatively, and echocardiography was performed at 4 to 6 weeks. Right heart dilatation was assessed using computed tomography after 6 weeks. Results Moderate to severe or torrential tricuspid regurgitation occurred immediately after the procedure in 12 of 13 animals. The jet was directed toward the septum in five of seven animals in the inferior vena cava group and toward the posterolateral side in four of six animals in the superior vena cava group. The dimensions of the right heart (right atrium, ventricle, and tricuspid valve annulus) were significantly enlarged at the 4- to 6-week follow-up echocardiographic examination and confirmed to be enlarged by computed tomography, independent of the route used. Conclusion The loop wire cutting method successfully induced a disease model of tricuspid regurgitation while controlling the regurgitation jet direction via two procedural routes. |
| first_indexed | 2024-04-24T22:53:16Z |
| format | Article |
| id | doaj.art-1867169ce1104ea4b866e64331bfa520 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-24T22:53:16Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-1867169ce1104ea4b866e64331bfa5202024-03-18T10:05:12ZengSAGE PublishingJournal of International Medical Research1473-23002024-03-015210.1177/03000605241233524Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routesJi Soo OhGa Yun KimSeok Hyun KimSang Hyun LeeYong Hyun ParkJune Hong KimMin Ku ChonObjective To develop an experimental porcine model of tricuspid regurgitation using two induction routes: the inferior vena cava and superior vena cava. Methods Tricuspid regurgitation was generated using the loop wire cutting method. The tricuspid regurgitation jet direction was controlled by accessing the valve through the inferior (n = 7) or superior (n = 6) vena cava. The occurrence, direction, and progression of tricuspid regurgitation were assessed postoperatively, and echocardiography was performed at 4 to 6 weeks. Right heart dilatation was assessed using computed tomography after 6 weeks. Results Moderate to severe or torrential tricuspid regurgitation occurred immediately after the procedure in 12 of 13 animals. The jet was directed toward the septum in five of seven animals in the inferior vena cava group and toward the posterolateral side in four of six animals in the superior vena cava group. The dimensions of the right heart (right atrium, ventricle, and tricuspid valve annulus) were significantly enlarged at the 4- to 6-week follow-up echocardiographic examination and confirmed to be enlarged by computed tomography, independent of the route used. Conclusion The loop wire cutting method successfully induced a disease model of tricuspid regurgitation while controlling the regurgitation jet direction via two procedural routes.https://doi.org/10.1177/03000605241233524 |
| spellingShingle | Ji Soo Oh Ga Yun Kim Seok Hyun Kim Sang Hyun Lee Yong Hyun Park June Hong Kim Min Ku Chon Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes Journal of International Medical Research |
| title | Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| title_full | Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| title_fullStr | Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| title_full_unstemmed | Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| title_short | Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| title_sort | novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes |
| url | https://doi.org/10.1177/03000605241233524 |
| work_keys_str_mv | AT jisoooh novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT gayunkim novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT seokhyunkim novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT sanghyunlee novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT yonghyunpark novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT junehongkim novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes AT minkuchon novelpercutaneoustechniqueforcreationofporcinemodeloftricuspidregurgitationviatworoutes |