Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause
The formation of the MS cluster starting from insulin resistance (IR), visceral obesity, dyslipidemia, arterial hypertension and carbohydrate metabolism disorders (CMD) against the background of estrogenic deficiency defines postmenopause as a risk factor for type 2 diabetes mellitus (DM2) and incre...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2019-08-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/3121 |
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| author | L. A. Ruyatkina D. S. Ruyatkin I. S. Iskhakova L. V. Scherbakova |
| author_facet | L. A. Ruyatkina D. S. Ruyatkin I. S. Iskhakova L. V. Scherbakova |
| author_sort | L. A. Ruyatkina |
| collection | DOAJ |
| description | The formation of the MS cluster starting from insulin resistance (IR), visceral obesity, dyslipidemia, arterial hypertension and carbohydrate metabolism disorders (CMD) against the background of estrogenic deficiency defines postmenopause as a risk factor for type 2 diabetes mellitus (DM2) and increased cardiovascular risk. The TyG index (logarithmic ratio of triglyceride and fasting plasma glucose levels) is proposed for surrogate evaluation of IR, reflecting an integrated approach to metabolic disorders.Aim: To assess the relationship between the TyG Index and HOMA2-IR and its informativeness in predicting the risk of DM2 in women in postmenopause.Materials and methods: TyG and HOMA2-IR indices (C-peptide) were determined in 94 postmenopausal women 58.02 ± 5.88 years of age, evaluated according to NCEP ATP III criteria and divided into groups: 1st - DM2, 2nd - prediabetes, 3rd - without CMD (HbAlc 7.3 ± 1.0; 6.2 ± 0.2 and 5.5 ± 0.4%, respectively). By means of SPSS (version 17) we evaluated ME (25-75%); intergroup differences by Mann-Whitney criteria; we performed correlation and ROC-analysis.Results: TyG correlates with HOMA2IR in group 2 (R = 0.61; p = 0.013) and 3 (R = 0.60; p = 0.001). In the process of ROC-analysis cut-off for TyG was revealed, reflecting the chance of presence of DM2 in groups 2 and 3: 7.5 (sensitivity 0.938 and specificity 0.813) and 8.0 (sensitivity 0.894 and specificity 0.810), respectively.Conclusion: TyG index allows predicting the development of dysglycemia in women in postmenopause with the signs of MS through the phenomenon of lipoglucotoxicity. |
| first_indexed | 2024-04-09T16:43:10Z |
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| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:43:10Z |
| publishDate | 2019-08-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-186734379b0f4edc8c77871c61b2e9c22023-04-23T06:56:34ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-08-0104889310.21518/2079-701X-2019-4-88-933029Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopauseL. A. Ruyatkina0D. S. Ruyatkin1I. S. Iskhakova2L. V. Scherbakova3Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian FederationFederal State Budgetary Educational Institution of Higher Education «Novosibirsk State Medical University» of the Ministry of Health of the Russian FederationState Budgetary Healthcare Institution of the Novosibirsk Region City Clinical Hospital No. 1Research Institute of Therapy and Preventive Medicine - branch of the Federal State Budgetary Scientific Institution Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of SciencesThe formation of the MS cluster starting from insulin resistance (IR), visceral obesity, dyslipidemia, arterial hypertension and carbohydrate metabolism disorders (CMD) against the background of estrogenic deficiency defines postmenopause as a risk factor for type 2 diabetes mellitus (DM2) and increased cardiovascular risk. The TyG index (logarithmic ratio of triglyceride and fasting plasma glucose levels) is proposed for surrogate evaluation of IR, reflecting an integrated approach to metabolic disorders.Aim: To assess the relationship between the TyG Index and HOMA2-IR and its informativeness in predicting the risk of DM2 in women in postmenopause.Materials and methods: TyG and HOMA2-IR indices (C-peptide) were determined in 94 postmenopausal women 58.02 ± 5.88 years of age, evaluated according to NCEP ATP III criteria and divided into groups: 1st - DM2, 2nd - prediabetes, 3rd - without CMD (HbAlc 7.3 ± 1.0; 6.2 ± 0.2 and 5.5 ± 0.4%, respectively). By means of SPSS (version 17) we evaluated ME (25-75%); intergroup differences by Mann-Whitney criteria; we performed correlation and ROC-analysis.Results: TyG correlates with HOMA2IR in group 2 (R = 0.61; p = 0.013) and 3 (R = 0.60; p = 0.001). In the process of ROC-analysis cut-off for TyG was revealed, reflecting the chance of presence of DM2 in groups 2 and 3: 7.5 (sensitivity 0.938 and specificity 0.813) and 8.0 (sensitivity 0.894 and specificity 0.810), respectively.Conclusion: TyG index allows predicting the development of dysglycemia in women in postmenopause with the signs of MS through the phenomenon of lipoglucotoxicity.https://www.med-sovet.pro/jour/article/view/3121insulin resistancepostmenopausemetabolic syndrometyg indexhoma2-irlipoglucotoxicitytype 2 diabetes mellituscardiovascular risk |
| spellingShingle | L. A. Ruyatkina D. S. Ruyatkin I. S. Iskhakova L. V. Scherbakova Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause Медицинский совет insulin resistance postmenopause metabolic syndrome tyg index homa2-ir lipoglucotoxicity type 2 diabetes mellitus cardiovascular risk |
| title | Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| title_full | Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| title_fullStr | Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| title_full_unstemmed | Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| title_short | Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| title_sort | possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause |
| topic | insulin resistance postmenopause metabolic syndrome tyg index homa2-ir lipoglucotoxicity type 2 diabetes mellitus cardiovascular risk |
| url | https://www.med-sovet.pro/jour/article/view/3121 |
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