Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene SCN1A which encodes the voltage gated sodium (Na+) channel subunit Nav1.1. GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs) exhibit impaired excita...

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Bibliographic Details
Main Authors: Kevin M Goff, Ethan M Goldberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
epilepsy
Nav1.1
SCN1A
electrophysiology
ion channels
Online Access:https://elifesciences.org/articles/46846

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