The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

The role of pro-opiomelanocortin in the ACTH–cortisol dissociation of sepsis

Abstract Background Sepsis is typically hallmarked by high plasma (free) cortisol and suppressed cortisol breakdown, while plasma adrenocorticotropic hormone (ACTH) is not increased, referred to as ‘ACTH–cortisol dissociation.’ We hypothesized that sepsis acutely activates the hypothalamus to genera...

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Bibliographic Details
Main Authors: Arno Téblick, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Tim Van Oudenhove, Lies Langouche, Greet Van den Berghe
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Critical Care
Subjects:
Sepsis
Pituitary
Adrenal
Adrenocorticotropic hormone
Pro-opiomelanocortin
Glucocorticoid receptor
Online Access:https://doi.org/10.1186/s13054-021-03475-y

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