A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes

A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes

ABSTRACT Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by binding and inactivating the PrfA virulence activator. I...

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Main Authors: Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
2-pyridones
BrtA
Listeria monocytogenes
PrfA
antibacterial
antibiotic
Online Access:https://journals.asm.org/doi/10.1128/mbio.00449-23

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