Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana
Abstract Background and Aims Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication‐related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study d...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
|
| Series: | Health Science Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/hsr2.1297 |
| _version_ | 1797791497941155840 |
|---|---|
| author | Peter K. Selleh Enoch O. Anto Wina I. O. Boadu Benedict Sackey Lilian A. Boateng Charles Nkansah Frederick Nsafoah Abdul R. Saasi Selina Mintaah Yaw A. Wiafe Charles Derigubah Emmanuel E. Korsah Joseph Frimpong Ezekiel Ansah Valentine C. K. T. Tamakloe Patrick Adu Joseph Boachie Otchere Addai‐Mensah |
| author_facet | Peter K. Selleh Enoch O. Anto Wina I. O. Boadu Benedict Sackey Lilian A. Boateng Charles Nkansah Frederick Nsafoah Abdul R. Saasi Selina Mintaah Yaw A. Wiafe Charles Derigubah Emmanuel E. Korsah Joseph Frimpong Ezekiel Ansah Valentine C. K. T. Tamakloe Patrick Adu Joseph Boachie Otchere Addai‐Mensah |
| author_sort | Peter K. Selleh |
| collection | DOAJ |
| description | Abstract Background and Aims Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication‐related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. Methods This case–control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid‐phase sandwich enzyme‐linked immunosorbent assay method. Data were analyzed using R language software. Results Plasma PAI‐1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control (p < 0.0001). There was no significant difference in plasma TAFI levels between the participants with poor glycemic control as compared to participants with good glycemic control (p = 0.900). T2DM patients had significantly shorter APTT, PT, and INR than controls (p < 0.05). At a cut‐off of ≥161.70 pg/μL, PAI was independently associated with increasing odds (adjusted odds ratio = 13.71, 95% confidence interval: 3.67–51.26, p < 0.0001) of poor glycemic control and showed the best diagnostic accuracy for poor glycemic control (area under the curve = 0.85, p < 0.0001). Conclusion PAI‐1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI‐1 is required to prevent hypercoagulability and thrombotic disorders. |
| first_indexed | 2024-03-13T02:19:41Z |
| format | Article |
| id | doaj.art-186aad1483d34c21ad28f11f3fd41e0e |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-13T02:19:41Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-186aad1483d34c21ad28f11f3fd41e0e2023-06-30T10:20:50ZengWileyHealth Science Reports2398-88352023-06-0166n/an/a10.1002/hsr2.1297Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, GhanaPeter K. Selleh0Enoch O. Anto1Wina I. O. Boadu2Benedict Sackey3Lilian A. Boateng4Charles Nkansah5Frederick Nsafoah6Abdul R. Saasi7Selina Mintaah8Yaw A. Wiafe9Charles Derigubah10Emmanuel E. Korsah11Joseph Frimpong12Ezekiel Ansah13Valentine C. K. T. Tamakloe14Patrick Adu15Joseph Boachie16Otchere Addai‐Mensah17Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast GhanaDepartment of Medical Laboratory Science, School of Allied Health Sciences University of Cape Coast Cape Coast GhanaDepartment of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi GhanaAbstract Background and Aims Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication‐related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. Methods This case–control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid‐phase sandwich enzyme‐linked immunosorbent assay method. Data were analyzed using R language software. Results Plasma PAI‐1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control (p < 0.0001). There was no significant difference in plasma TAFI levels between the participants with poor glycemic control as compared to participants with good glycemic control (p = 0.900). T2DM patients had significantly shorter APTT, PT, and INR than controls (p < 0.05). At a cut‐off of ≥161.70 pg/μL, PAI was independently associated with increasing odds (adjusted odds ratio = 13.71, 95% confidence interval: 3.67–51.26, p < 0.0001) of poor glycemic control and showed the best diagnostic accuracy for poor glycemic control (area under the curve = 0.85, p < 0.0001). Conclusion PAI‐1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI‐1 is required to prevent hypercoagulability and thrombotic disorders.https://doi.org/10.1002/hsr2.1297coagulationglycemic controlplasminogen activator inhibitorthrombin activatable fibrinolysis inhibitortype 2 diabetes mellitus |
| spellingShingle | Peter K. Selleh Enoch O. Anto Wina I. O. Boadu Benedict Sackey Lilian A. Boateng Charles Nkansah Frederick Nsafoah Abdul R. Saasi Selina Mintaah Yaw A. Wiafe Charles Derigubah Emmanuel E. Korsah Joseph Frimpong Ezekiel Ansah Valentine C. K. T. Tamakloe Patrick Adu Joseph Boachie Otchere Addai‐Mensah Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana Health Science Reports coagulation glycemic control plasminogen activator inhibitor thrombin activatable fibrinolysis inhibitor type 2 diabetes mellitus |
| title | Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana |
| title_full | Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana |
| title_fullStr | Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana |
| title_full_unstemmed | Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana |
| title_short | Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the Upper West Region, Ghana |
| title_sort | quality of glycemic control in type 2 diabetes mellitus t2dm and its association with markers of coagulation and inhibitors of fibrinolysis a case control study in the upper west region ghana |
| topic | coagulation glycemic control plasminogen activator inhibitor thrombin activatable fibrinolysis inhibitor type 2 diabetes mellitus |
| url | https://doi.org/10.1002/hsr2.1297 |
| work_keys_str_mv | AT peterkselleh qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT enochoanto qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT winaioboadu qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT benedictsackey qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT lilianaboateng qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT charlesnkansah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT fredericknsafoah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT abdulrsaasi qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT selinamintaah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT yawawiafe qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT charlesderigubah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT emmanuelekorsah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT josephfrimpong qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT ezekielansah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT valentineckttamakloe qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT patrickadu qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT josephboachie qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana AT otchereaddaimensah qualityofglycemiccontrolintype2diabetesmellitust2dmanditsassociationwithmarkersofcoagulationandinhibitorsoffibrinolysisacasecontrolstudyintheupperwestregionghana |