Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction
Bacground/Aim. Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2013-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501303284V.pdf |
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| author | Velojić-Golubović Milena Dimić Dragan Antić Slobodan Radenković Saša Đinđić Boris Jovanović Miodrag |
| author_facet | Velojić-Golubović Milena Dimić Dragan Antić Slobodan Radenković Saša Đinđić Boris Jovanović Miodrag |
| author_sort | Velojić-Golubović Milena |
| collection | DOAJ |
| description | Bacground/Aim. Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin resistance and cardiovascular disease. Leptin and adiponectin are considered to be the most important adipokines with the potential metabolic and cardiovascular effects. Body weight loss improves insulin sensitivity and decreases risk for most complications associated with obesity. The aim of this study was to determine the effects of moderate loss of body weight on the level of leptin and adiponectin, insulin sensitivity and abnormalities of glycoregulation in obese women, to determine whether and to what extent the secretory products of adipose tissue, leptin and adiponectin contribute to insulin sensitivity, as well as to assess their relationship and influence on glycemia and insulinemia during the period of losing body weight using a calorie restricted diet. Methods. The study involved 90 obese female subjects (BMI |
| first_indexed | 2024-12-14T05:23:58Z |
| format | Article |
| id | doaj.art-186b68de53f54a36af61f1242a4dc528 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-14T05:23:58Z |
| publishDate | 2013-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-186b68de53f54a36af61f1242a4dc5282022-12-21T23:15:34ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502013-01-0170328429110.2298/VSP1303284VRelationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restrictionVelojić-Golubović MilenaDimić DraganAntić SlobodanRadenković SašaĐinđić BorisJovanović MiodragBacground/Aim. Visceral fat is highly active metabolic and endocrine tissue which secretes many adipokines that act both on local and systemic level. It is believed that adipokines and "low-grade inflammatory state" represent a potential link between obesity, metabolic syndrome, insulin resistance and cardiovascular disease. Leptin and adiponectin are considered to be the most important adipokines with the potential metabolic and cardiovascular effects. Body weight loss improves insulin sensitivity and decreases risk for most complications associated with obesity. The aim of this study was to determine the effects of moderate loss of body weight on the level of leptin and adiponectin, insulin sensitivity and abnormalities of glycoregulation in obese women, to determine whether and to what extent the secretory products of adipose tissue, leptin and adiponectin contribute to insulin sensitivity, as well as to assess their relationship and influence on glycemia and insulinemia during the period of losing body weight using a calorie restricted diet. Methods. The study involved 90 obese female subjects (BMIhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501303284V.pdfobesityleptinadiponectinbody mass indexwomendiet, reducinginsulin resistance |
| spellingShingle | Velojić-Golubović Milena Dimić Dragan Antić Slobodan Radenković Saša Đinđić Boris Jovanović Miodrag Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction Vojnosanitetski Pregled obesity leptin adiponectin body mass index women diet, reducing insulin resistance |
| title | Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction |
| title_full | Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction |
| title_fullStr | Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction |
| title_full_unstemmed | Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction |
| title_short | Relationship of adipokine to insulin sensitivity and glycemic regulation in obese women: The effect of body weight reduction by caloric restriction |
| title_sort | relationship of adipokine to insulin sensitivity and glycemic regulation in obese women the effect of body weight reduction by caloric restriction |
| topic | obesity leptin adiponectin body mass index women diet, reducing insulin resistance |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501303284V.pdf |
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