Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.
The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2009-08-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2714070?pdf=render |
| _version_ | 1811268276382072832 |
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| author | Shenghua Li Paul Brazhnik Bruno Sobral John J Tyson |
| author_facet | Shenghua Li Paul Brazhnik Bruno Sobral John J Tyson |
| author_sort | Shenghua Li |
| collection | DOAJ |
| description | The asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alpha-proteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine (e.g., Rhizobium, Brucella). |
| first_indexed | 2024-04-12T21:20:00Z |
| format | Article |
| id | doaj.art-186b763a9fda41aa9d69c8e188d7d7b1 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-12T21:20:00Z |
| publishDate | 2009-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-186b763a9fda41aa9d69c8e188d7d7b12022-12-22T03:16:20ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582009-08-0158e100046310.1371/journal.pcbi.1000463Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus.Shenghua LiPaul BrazhnikBruno SobralJohn J TysonThe asymmetric cell division cycle of Caulobacter crescentus is orchestrated by an elaborate gene-protein regulatory network, centered on three major control proteins, DnaA, GcrA and CtrA. The regulatory network is cast into a quantitative computational model to investigate in a systematic fashion how these three proteins control the relevant genetic, biochemical and physiological properties of proliferating bacteria. Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme. The model is validated against observed phenotypes of wild-type cells and relevant mutants, and it predicts the phenotypes of novel mutants and of known mutants under novel experimental conditions. Because the cell cycle control proteins of Caulobacter are conserved across many species of alpha-proteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture and medicine (e.g., Rhizobium, Brucella).http://europepmc.org/articles/PMC2714070?pdf=render |
| spellingShingle | Shenghua Li Paul Brazhnik Bruno Sobral John J Tyson Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. PLoS Computational Biology |
| title | Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
| title_full | Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
| title_fullStr | Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
| title_full_unstemmed | Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
| title_short | Temporal controls of the asymmetric cell division cycle in Caulobacter crescentus. |
| title_sort | temporal controls of the asymmetric cell division cycle in caulobacter crescentus |
| url | http://europepmc.org/articles/PMC2714070?pdf=render |
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