Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis

Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis

Abstract The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX inhibits cellular p53 activity, which is highly relevant to cancer occurrence. Coiled-coil domain-containing protein 106 (CCDC1...

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Bibliographic Details
Main Authors:	Ting Zhou, Zhiqiang Ke, Qianqian Ma, Jiani Xiang, Meng Gao, Yongqi Huang, Xiyao Cheng, Zhengding Su
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-47808-z

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