The Migration of Cancer Cells in Gradually Varying Chemical Gradients and Mechanical Constraints

The Migration of Cancer Cells in Gradually Varying Chemical Gradients and Mechanical Constraints

We report a novel approach to study cell migration under physical stresses by utilizing established growth factor chemotaxis. This was achieved by studying cell migration in response to epidermal growth factor (EGF) chemoattraction in a gradually tapered space, imposing mechanical stresses. The devi...

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Bibliographic Details
Main Authors: Smitha M. N. Rao, Uday Tata, Victor K. Lin, Jung-Chih Chiao
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Micromachines
Subjects:
microfluidics
tapered channels
chemotaxis
cell migration
cancer metastasis
Online Access:http://www.mdpi.com/2072-666X/5/1/13

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