Design, synthesis of new 2,4-thiazolidinediones: In-silico, in-vivo anti-diabetic and anti-inflammatory evaluation

Design, synthesis of new 2,4-thiazolidinediones: In-silico, in-vivo anti-diabetic and anti-inflammatory evaluation

In this study, a series of nine novel heterocyclic compounds were synthesized through a concise three-step reaction process. The synthesis involved Knoevenagel condensation at the 5th position of the 2,4-thiazolidinedione or rhodanine ring-system. Comprehensive physicochemical and spectral analyses,...

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Bibliographic Details
Main Authors: Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, N.A. Khatib, Rohini S. Kavalapure, B.R. Prashantha Kumar, Vinod D, Nandkishor B. Bavage
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Thiazolidinedione
Antidiabetic
Antiinflammatory
Glucose uptake
In-vivo
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000232

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